Research:
The application of novel methodologies for studying biology at a genome-wide level has been a remarkably successful means of cataloging the components required for many cellular processes. At the same time, however, this has created a bottleneck at the level of going from parts lists to functional and mechanistic insights. Nowhere is this more apparent than in the study of membrane-associated processes. This area of cell biology has been particularly difficult to dissect by classical biochemistry but now stands poised to benefit from targeted and systematic biochemical reconstitution strategies that make use of the identified components. My lab is interested in bridging this post-genomic gap as it pertains to the study of very long-chain fatty acids, insertion of tail-anchored proteins into the endoplasmic reticulum membrane, and autophagy.
Selected Publications: Schuldiner M., Metz J., Schmid V., Denic V. et al. (2008), The Get Complex Mediates Insertion of Tail-Anchored Proteins into the ER. Cell; 134, 634-45. Denic V., Weissman J. S. (2007) A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length. Cell; 130, 663-677 Denic V., Quan E.M., and Weissman, J. S. (2006) A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for Endoplasmic Reticulum-Associated Degradation. Cell; 126, 349-359. Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V. et al. (2005) Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile. Cell; 123, 507-519 Bhamidipati, A., Denic, V., Quan, E. M., and Weissman, J. S. (2005). Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER lumen. Molecular Cell; 19, 741-751. |
