Ramalho-Santos, M., Yoon, S., Matsuzaki, Y., Mulligan, R. C., and Melton, D. A. (2002). ‘Stemness’: transcriptional profiling of embryonic and adult stem cells. Science (in press). Raw data

Scearce, L.M., Brestelli, J.E., McWeeney, S.K., Lee, C.S., Mazzarelli, J., Pinney, D.F., Pizarro, A., Stoeckert, C.J. Jr., Clifton, S.W., Permutt, M.A., Brown, J., Melton, D.A., and Kaestner, K.H. (2002). Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes. 51:1997-2004.

Gu, G., Dubauskate, J., and Melton, D.A. (2002). Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 129:2447-57.

Fishman, M.P., and Melton, D.A. (2002). Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. Int. J. Dev. Biol. 46:201-7.

Lammert, E., Cleaver, O., and Melton, D. (2001). Induction of Pancreatic Differentiation by Signals from Blood Vessels. Science. 294:564-7.

Grapin-Botton, A., Majithia, A.R., and Melton, D.A. (2001). Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 15:444-54.

Hebrok, M., Kim, S.K., St Jacques, B., McMahon, A.P., and Melton, D.A.(2001). Regulation of pancreas development by hedgehog signaling. Development. 127:4905-13.

Huang, H., Vogel, S.S., Liu, N., Melton, D.A., and Lin, S. (2001). Analysis of pancreatic development in living transgenic zebrafish embryos. Mol. Cell Endocrinol. 177:117-24.

Schuldiner, M., Yanuka, O., Itskovitz-Eldor, J., Melton, D.A., and Benvenisty, N. (2000). Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA. 97:11307-12.

Kim, S.K., Hebrok, M., Li, E., Oh, S.P., Schrewe, H., Harmon, E.B., Lee, J.S., and Melton, D.A. (2000). Activin receptor patterning of foregut organogenesis. Genes Dev. 14:1866-1871.

Kelly, O.G., and Melton, D.A. (2000). Development of the pancreas in Xenopus laevis. Dev. Dyn. 218:615-627.

Lammert, E., Brown, J., and Melton, D.A. (2000). Notch gene expression during pancreatic organogenesis. Mech. Dev. 94:199-203.

Ramalho-Santos, M., Melton, D.A., and McMahon, A.P. (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 127:2763-2772.

Wells, J.M. and Melton, D.A. (2000). Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development. 127:1563-1572.

Grapin-Botton, A. and Melton, D.A. (2000). Endoderm development: from patterning to organogenesis. Trends Genet. 16:124-130.

Wells, J. M. and Melton, D. A. (1999). Vertebrate endoderm development. Annu. Rev. Cell Dev. Biol. 15:393-410.

Hebrok, M., Kim, S.K. and Melton, D.A. (1999). Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 48:1550-1556.

Kim, S.K. and Melton, D.A. (1998). Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor. Proc. Nat. Acad. Sci. 95:13036-13041.

Joseph, E. M. and Melton, D. A. (1998). Mutant Vg1 ligands disrupt endoderm and mesoderm formation in Xenopus embryos. Development. 125:2677-2685.

Henry, G. L. and Melton, D. A. (1998). Mixer, a novel homeobox gene, is required for endoderm development. Science. 281: 91-96.

Hebrok, M., Kim, S. K. and Melton, D. A. (1998). Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes & Development. 12:1705-1713

Kim, S. K., Hebrok, M. and Melton, D. A. (1997). Pancreas development in the chick embryo. Cold Spring Harbor Symposia on Quantitative Biology. LXII. 377-383.

Kim, S. K., Hebrok, M. and Melton, D. A. (1997). Notochord to endoderm signaling is required for pancreas development. Development. 124:4243-4252.

Joseph, E. M. and Melton, D. A. (1997). Xnr4: A Xenopus Nodal-Related Gene Expressed in the Spemann Organizer. Developmental Biology. 184:367-372.

Hemmati-Brivanlou, A. and Melton, D. A. (1997). Vertebrate Neural Induction. Annual Reviews for Neuroscience. 20:43-60.

Reilly, K. M., and Melton, D.A. (1996). Short-range signaling by candidate morphogens of the TGFß family and the evidence for a relay mechanism of induction. Cell. 86:743-754.

Klein, P. S. and Melton, D. A. (1996). A molecular mechanism for the effect of lithium on development. Proc. Nat. Acad. Sci. 93:8455-8459.

Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A. and Gelbart, W. M. (1996). Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-ß responsive cells. Development. 122:2099-2108.

Graff, J. M., Bansal, A. and Melton, D. A. (1996). Xenopus mad proteins transduce distinct subsets of signals for the TGF-ß superfamliy. Cell. 85:479-487.

Dohrmann, C. E., Kessler, D. S. and Melton, D. A. (1996). Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1. Developmental Biology. 175:108-117.

Henry, G. L., Brivanlou, I. H., Kessler, D. S., Hemmati-Brivanlou, A. and Melton, D. A. (1996). TGF-ß signals and a prepattern in Xenopus laevis endodermal development. Development. 122:1007-1015.

Reilly, K. M., and Melton, D.A. (1996). The role of short-range and long-range signaling in mesoderm induction and patterning during Xenopus development. Seminars in Cell & Developmental Biology. v.7:77-85.

Kessler, D. S., and Melton, D.A. (1995). Induction of dorsal mesoderm by soluble, mature Vg1 protein. Development 121:2155-2164.

Kelly, O.G., and Melton, D.A. (1995). Induction and patterning of the vertebrate nervous system. Trends in Genetics. v.11:273-278.

Kessler, D. S., and Melton, D.A. (1994). Vertebrate embryonic induction: Mesodermal and neural patterning. Science. 266:596-604.

Graff, J.M., Thies, R.S., Song, J.J., Celeste, A.J. and Melton, D.A. (1994). Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in Vivo. Cell. 79:169-179.

Klein, P. and Melton, D.A. (1994). Translation initiation factor 4E induces mesoderm in Xenopus laevis embryos. Science. 265:803-806.

Wilson, P. A., and Melton, D.A. (1994). Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Current Biology. v.4:676-686.

Hemmati-Brivanlou, A., Kelly, O.G., and Melton, D.A. (1994). Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 77:283-295.

Hemmati-Brivanlou, A., and Melton, D.A. (1994). Inhibition of activin receptor signaling promotes neuralization in Xenopus laevis. Cell. 77:273-281.

Klein, P.S., and Melton, D.A. (1994). Hormonal regulation of embryogenesis: The formation of mesoderm in Xenopus Laevis. Endocrine Reviews.v.15:326-341.

Thomsen, J. and Melton, D.A. (1993). Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell 74: 433-441.

Ku, M., and Melton, D.A. (1993) Xwnt-11: a maternally expressed Xenopus wnt gene. Development 119: 1161-1173.

Steinbeisser, H., De Robertis, E.M., Ku, M., Kessler, D.S., and Melton, D.A. (1993). Xenopus axis formation: induction of goosecoid by injected Wnt and activin mRNAs. Development 118:499-507.

Dohrmann, C.E., Hemmati-Brivanlou, A., Thomsen, G.H., Fields, A., Woolf, T.M., and Melton, D.A. (1993). Expression of activin mRNA during early development in Xenopus laevis. Developmental Biology 157:474-483.

Hemmati-Brivanlou, A. and Melton, D.A. (1992). A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature 359: 609-614.

Sokol, S. and Melton, D.A. (1992). Interaction of Wnt and activin mesoderm induction in Xenopus. Developmental Biology 154:348-355.

Woolf, T., Melton, D., and Jennings, C.G. (1992). Specificity of antisense oligonucleotides in vivo. Proc. Nat. Acad. Sci. 89:7305-7309.

Hemmati-Brivanlou, A., Wright, D.A., and Melton, D.A. (1992). Embryonic expression and functional analysis of a Xenopus activin receptor. Developmental Dynamics 194:1-11.

Whitman, M. and Melton, D.A. (1992). Involvment of p21ras in Xenopus mesoderm induction. Nature 357:252-254.

Jessell, T.M. and Melton, D.A. (1992). Diffusible factors in vertebrate embryonic induction. Cell 68:257-270.

Ruiz i Altaba, A., Choi, T., and Melton, D.A. (1992). Expression of the Xhox3 homeobox protein in Xenopus embryos: Blocking its early function suggests the requirement of Xhox3 for normal posterior development. Development Growth & Differentiation 33:651-669.

Mowry, K.L. and Melton, D.A. (1992). A 340-nt RNA sequence element directs vegetal localization in Xenopus oocytes. Science 255: 991-994.

Sokol, S., Christian, J., Moon, R. and Melton, D.A. (1991). Injected Wnt but not activin RNA induces a complete dorsal axis in Xenopus embryos. Cell 67: 741-752.

Gururajan, R., Perry-O’Keefe, H., Melton, D.A. and Weeks, D.L. (1991). The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase. Nature 349: 717-719.

Sokol, S. and Melton, D.A. (1991). Induction of Xenopus animal pole cells by activin reveals a preexistent pattern in the responding cells. Nature 351:409-411.

Melton, D.A. (1991). Pattern Formation During Animal Development. Science 252: 234-241.

Mitrani, E. Ziv, T., Thomsen, J., Shimoni, Y., Melton, D.A., and Bril, A. (1990). Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick. Cell 63(3): 495-501.

Thomsen, G., Woolf, T., Whitman, M., Sokol, S., Vaughan, J., Vale, W., and Melton, D.A. (1990). Activins are expressed in early Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell 63(3): 485-493.

Sokol, S., Wong, G. and Melton, D.A. (1990). A mouse macrophage factor induces head structures and organizes a body axis in Xenopus. Science 249:561-564.

Woolf, T.M., Jennings, C.G.B., Rebagliati, M. and Melton, D.A.(1990). The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Research 18(7): 1763-1769.

Yisraeli, J., Sokol, S. and Melton, D.A. (1990). A two-step model for the localization of maternal mRNA in Xenopus oocytes: Involvement of microtubules and microfilaments in the translocation and anchoring of Vg1 mRNA. Development. 108:289-298.

Yisraeli, J. Sokol, S. and Melton, D.A. (1989). The process of localizing a maternal messenger RNA in Xenopus oocytes. Development 1989 Supplement: 31-36.

Tannahill, D. and Melton, D.A. (1989). Localized synthesis of the VG1 protein during early Xenopus development. Development 106(4):775-785.

Ruiz i Altaba, A. and Melton, D.A. (1990). Axial patterning and the establishment of polarity in the frog embryo. Trends in Genetics 6: 57-64.

Kondiah, P., Sands, M.J., Smith, J.M., Fields, A., Roberts, A.B., Sporn, M.B., and Melton, D.A. (1990). Identification of a novel transforming growth factor (TGFß5) mRNA in Xenopus laevis. The Journal of Biological Chemistry 265:1089-1093.

Whitman, M. and Melton, D.A. (1989). Growth factors in early embryogenesis. Annual Review of Cell Biology 5:93-117.

Ruiz i Altaba, A. and Melton, D.A. (1989). Interaction between peptide growth factors and homeobox genes in the establishment of anterior-posterior polarity in frog embryos. Nature 341:33-38.

Melton, D.A., Ruiz i Altaba, A., Yisraeli, J. and Sokol, S. (1989). Localization of mRNA and axis formation during Xenopus embryogenesis. CIBA Foundation Symposium 144:16-36.

Whitman, M. and Melton, D.A. (1989). Induction of mesoderm by a viral oncogene in early Xenopus embryos. Science 244:803-806.

Ruiz i Altaba, A. and Melton, D.A. (1989). Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development. Development 106:173-183.

Ruiz i Altaba, A. and Melton, D.A. (1989). Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Cell 57:317-326.

Krieg, P.A., Varnum, S.M., Wormington, M.W. and Melton, D.A. (1989). The mRNA encoding elongation factor 1a (EF1a) is a major transcript at the midblastula transition in Xenopus. Developmental Biology 133:93-100.

Yisraeli, J. and Melton, D.A. (1988). The maternal mRNA Vg1 is correctly localized following injection into Xenopus oocytes. Nature 336:592-595.

Mercola, M., Melton, D.A. and Stiles, C.D. (1988). Platelet-derived growth factors A chain is maternally encoded in Xenopus embryos. Science 241:1223-1225.

Harvey, R.P. and Melton, D.A. (1988) Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos. Cell 53:687-697.

Weeks, D.L. and Melton, D.A. (1987). A maternal messenger RNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-ß. Cell 51:861-86.

Melton, D.A. (1987). Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes. Nature 328:80-82.

Ruiz i Altaba, A., Perry - O'Keefe, H., and Melton, D.A. (1987). Xfin: an embryonic gene encoding a multifingered protein in Xenopus. EMBO J. 6:3065-3070.

Krieg, P.A. and Melton, D.A. (1987) In vitro RNA synthesis with SP6 RNA polymerase. Methods in Enzymology, Recombinant DNA, ed by R. Wu. Part F. Vol 155:397-415.

Melton, D.A. (1987) Translation of messenger RNA in injected frog oocytes. Methods in Enzymology, Guide to Molecular Cloning, ed by S. Berger and A. Kimmel. Vol.152:288-296.

Weeks, D.L. and Melton, D.A. (1987). A maternal RNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase. PNAS 84:2798-2802.

Krieg, P.A. and Melton, D.A. (1987). An enhancer responsible for activating transcription at the mid-blastula transition in Xenopus development. PNAS 84:2331-2335.

Kintner, C.R. and Melton, D.A. (1987). Expression of N-CAM RNA in ectoderm is an early response to neural induction. Development 99:311-325.

Rebagliati, M.R. and Melton, D.A. (1987). Antisense RNA injections in frog eggs reveal an RNA duplex unwinding activity. Cell 48:599-605.

Melton, D. A. and Rebagliati, M.R. (1986). Antisense RNA injections in fertilized eggs as a test for the function of localized mRNAs. JEEM 97: 211-221.

Harvey, R.P., Tabin, C. and Melton, D.A. (1986). Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products. EMBO J. 5: 1267-1244.

Krieg, P.A., Rebagliati, M.R., Weeks, D.L., and Melton, D.A. (1986). Gene Activation during Xenopus embryogenesis. pp. 357-369. In Gametogenesis and the Early Embryo, ed. by J. Gall. Alan Liss, Inc., N.Y.

Weeks, D.L., Rebagliati, M.R., Harvey, R.P. and Melton, D.A. (1985). Localized maternal mRNAs in Xenopus laevis eggs. Cold Spring Harbor Symp. Quant. Biol. L: 21-30.

Kreig, P. A. and Melton, D. A. (1985) Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs. EMBO J. 4: 3463-3471.

Rebagliati, M.R., Weeks, D.L., Harvey, R.P. and Melton, D.A. (1985). Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell 42: 769-777.

Melton, D.A. (1985). Injected anti-sense RNAs specifically block messenger RNA translation in vivo. Proc. Natl. Acad. Sci. USA 82: 144-148.

Krieg, P.A. and Melton, D.A. (1984). Functional messenger RNAs are produced by SP6 in vitro transcription of cloned DNAs. Nucleic Acids Research 12: 7057-7070.

Melton, D.A., Krieg, P.A., Rebagliati, M.R., Maniatis, T., Zinn, K., and Green, M.R. (1984) Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research 12: 7035-7056.

Krieg, P. and Melton, D.A. (1984). Formation of the 3' end of histone mRNA by post-transcriptional processing. Nature 308: 203-206.

Perry, H. and Melton, D.A. (1983). A rapid increase in acetylcholinesterase mRNA during ascidian embyrogenesis as demonstrated by microinjection into Xenopus laevis oocytes. Cell Differentiation 13: 233-238.

Green, M.R., Maniatis, T. and Melton, D.A. (1983). Human ß globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell 32: 681-694.

Tranquilla, T., Cortese, R., Melton, D.A., and Smith, J.D. (1982). Sequences of four tRNA genes from Caenorhabditis elegans and the expression of C. elegans tRNA in Xenopus oocytes. Nucleic Acids Research 10: 7919-7934.

Ciampi, S., Melton, D.A., and Cortese, R. (1982). Site directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc. Nat. Acad. Sci. USA 79: 1388-1392.

Ciliberto, G., Castagnoli, L., Melton, D.A., and Cortese, R. (1982). Promoter of a eucaryotic tRNA gene is composed of three non-contiguous regions. Proc. Natl. Acad. Sci. USA 79: 1195-1199.

Miller, J. and Melton, D.A. (1981). A transcriptionally active pseudogene in Xenopuslaevis oocyte 5S DNA. Cell 24: 829-835.

Gurdon, J.B. and Melton, D.A. (1981). Gene transfer in amphibian eggs and oocytes.Ann. Rev. Genetics 15: 189-218.

Cortese, R., Harland, R. and Melton, D.A. (1980). In vivo transcription of tRNA genes: single stranded vs. double stranded templates. Proc. Natl. Acad. Sci. USA 77: 4147-4151.

Melton, D.A., DeRobertis, E., and Cortese, R. (1980). RNA processing: order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature 284: 143-148.

Melton, D.A. and Cortese, R. (1979). Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell 18: 1165-1172.

Gurdon, J.B., Melton, D.A. and DeRobertis, E. (1979). Genetics in an oocyte. Ciba Foundation Series 66: 63-80.

Cortese, R., Melton, D.A., Tranquilla, T. and Smith, J.D. (1978). Cloning of nematode tRNA genes and their expression in the frog ooctye. Nucleic Acids Research 5: 4593-4611.

Gottesfeld, J. and Melton, D.A. (1978). The length of nucleosome associated DNA is the same in both transcribed and non-transcribed regions of chromatin. Nature 273: 317-319.

Laskey, R.A. and Melton, D.A. (1977). Synthesis of SV40 DNA in eggs of Xenopus laevis in the absence of viral gene expression. Inserm 69: 253-258.