O'Shea Lab > People > Andrew Capaldi
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| Systems level behaviour
of the HOG MAPK pathway |
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| A remarkable feature of all cells is their ability
to convert signals, detected through ligand binding
at one or more receptor, into a precise change in
behaviour. In many cases the protein network that
is responsible for interpreting these signals is
well described, but it is not clear how the proteins
work together to yield the appropriate input-output
relationship. In order to understand some of the
principles behind such cellular circuits, we are
examining signal processing in the well-described
high osmolarity glycerol (HOG) response of budding
yeast. In particular, we are interested in understanding
how different levels of hyperosmotic stress lead
to different levels of gene expression. To do this
we are measuring the output, at different levels
of the HOG MAPK pathway, as a function of osmotic
stress. Using these data, together with a computer
model of the signalling pathway, we hope to identify
the mechanism by which a change in the level of
MAPK activation leads to a change in the transcriptional
response. |
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