2008 Undergraduate Honors Theses
submitted by Biochemical
Sciences, Chemical and Physical Biology, and Molecular and Cellular
Biology Concentrators
Michael Badgley, (BCHM)
Quantification of the magnitude of the hematopoietic stem cell
(HSC) bone marrow niche and its possible applications
Dr. David Scadden, Laboratory Sponsor
Brandon Darwin Bartch, (BCHM)
The Role of the Groucho/transducin-like Enhancer-of-split Protein
Family in the Mammalian Retina
Dr. Connie Cepko, Laboratory Sponsor
Michael Birnbaum, (CPB)
Synthesis and characterization of four putative kinase ligands
discovered through DNA-templated synthesis based in vitro
selections
Dr. David Liu, Laboratory Sponsor
Kelly Massiel Cadenas, (BCHM)
The Role of GlnA in Biofilm Formation by Bacillus subtilis
Dr. Richard Losick, Laboratory Sponsor
Joyce Chun-Ling Chang, (BCHM)
Targets of DNA damage response factors in B cells during class
switch recombination
Dr. John Manis, Laboratory Sponsor
Serene Imperia Chen, (BCHM)
Synapse elimination provokes strengthening of the axonal inputs
that innervate mouse submandibular ganglion neurons
Dr. Jeff Lichtman, Laboratory Sponsor
Daniel Choi, (BCHM)
Synthesis and Reactivity of Novel Organopalladium(IV) Fluoride
Complexes
Dr. Tobias Ritter, Laboratory Sponsor
Ian Dennis Chong, (BCHM)
The Effect of WASp/WIP phosphorylation on Natural Killer Cell
Cytotoxicity
Dr. Jack Strominger, Laboratory Sponsor
Jonathan Chow, (BCHM)
The Effect of HIV Infection on Proteasome Expression and
Activity
Dr. Sylvie Le, Laboratory Sponsor
Katharine Rose Clapham, (BCHM) - Henderson Prize, Hoopes
Prize
A tiny protein links two morphogenetic processes in a
bacterium
Dr. Richard Losick, Laboratory Sponsor
Victoria Clark, (BCHM) - Hoopes Prize
Alternative Splicing Factor Sfrs10 Is Required for Terminal
Differentiation of Rod Photoreceptor Outer Segments in the Mouse
Retina
Dr. Connie Cepko, Laboratory Sponsor
Brandon Geller, (BCHM)
A first molecular phylogeny for the timber beetle family
Cerambycidae; Relationships among Subfamilies
Dr. Brian Farrell, Laboratory Sponsor
Sharon Grossman, (CPB)
Predicting Expression Patterns from Promoter Sequences in the
Saccharomyces Cerevisiae PHO Pathway
Dr. Erin O'Shea, Laboratory Sponsor
Lewis Dirk Hahn, (BCHM)
1. Development and Characterization of a Tat-based Gene Delivery
System 2. Mediation of Gene Delivery of Lyophilized pDNA-polycation
Complexes by Structure
Dr. David Mooney, Laboratory Sponsor
Madelyn Ho, (CPB)
Characterization of the role of microsomal triglyceride transfer
protein in human CD1d-mediated antigen presentation
Dr. Richard Blumberg, Laboratory Sponsor
Jennifer W. Hsu, (BCHM)
Investigation of Lesions in TGF-β signaling pathways in Squamous
Cell Carcinoma
Dr. James Rheinwald, Laboratory Sponsor
Supriya K. Jain, (BCHM)
Genetic Characterization of Colorectal Cancer Tumor-Initiating
Cells
Dr. William Hahn, Laboratory Sponsor
Divya Jayaraman, (BCHM)
Development of a novel cell-free assay for detecting damage-induced
single-stranded gaps in chromatin using Xenopus laevis egg
extracts
Dr. Matthew Michael, Laboratory Sponsor
Gregory Alan Joice, (BCHM)
Characterization of Adult Zebrafish Renal Repair and the Role of
FGF Signaling
Dr. Alan Davidson, Laboratory Sponsor
Michelle Minsun Jung, (BCHM)
Gene Expression Analysis of MLKB1KO Mice: Identifying a novel link
between LKBI and the antioxidant GPX3
Dr. Laurie Goodyear, Laboratory Sponsor
Han Kim, (BCHM)
Synaptic Depression Following Postsynaptic Axotomy: Causes and
Consequences
Dr. Jeff Lichtman, Laboratory Sponsor
Bong Ihn Koh, (BCHM)
Investigation of a Lymphatic Component to the Hematopoietic Stem
Cell Microenvironment
Dr. David Scadden, Laboratory Sponsor
Richard R. Kronfol, (BCHM)
Acyl-Protein Thioesterase 1 and Modulation of Nitric Oxide
Synthase
Dr. Thomas Michel, Laboratory Sponsor
Rachel Lefebvre, (BCHM) - Hoopes Prize
Molecular dissection of TGF-β induced signal transduction pathways
controlling T-cell differentiation: I. Expression of
inhibitor-resistant type I TGF-β receptors in T-cells reveals that
inducible T regulatory cell development requires Smad activation.
II. Quantitative analysis of Foxp3 and RORɣt gene expression during
T-cell differentiation
Dr. Anjana Rao, Laboratory Sponsor
Yin Li, (BCHM)
FMRFamide-like Neuropeptides Modulate C. elegans Posture
Dr. Robert Horvitz, Laboratory Sponsor
Yuen-Joyce Liu, (BCHM)
Effect of Crohn’s disease associated mutations on the NOD2
signaling pathway
Dr. Koichi Kobayashi, Laboratory Sponsor
Eva Marie Luo, (BCHM)
Molecular Neuropathology of Aging: Characterization of Aging in the
Caribbean Vervet
Dr. Cynthia Lemere, Laboratory Sponsor
Matthew R. McFarlane, (BCHM)
Analysis of Multiple cis-Regulatory Elements Governing a Graded
Transcriptional Response of a Single Gene to a Mammalian
Morphogen
Dr. Andrew McMahon, Laboratory Sponsor
Kevin McMullen, (BCHM)
Reproductive Survival and DNA Double-Strand Breakage in Desiccated
Bdelloid Rotifer Adineta vaga
Dr. Matt Meselson, Laboratory Sponsor
Danny Mou, (BCHM) - Hoopes Prize
Edgetic-profiling of Disease-associated TP73L Mutant Proteins
Dr. Marc Vidal, Laboratory Sponsor
Melissa A. Mueller, (BCHM)
Involvement of Reactive Oxygen Species in Signaling Pathways
Regulating Cisplatin-induced Death of Zebrafish (Danio rerio)
Sensory Hair Cells
Dr. John Dowling, Laboratory Sponsor
Christopher Nabel, (BCHM)
Dynamics of Clathrin Coated Pit Formation at the Leading Edge of
Migrating Cells
Dr. Tomas Kirchhausen, Laboratory Sponsor
Lachezar Atanasov Nikolov, (BCHM)
Discovery of New Genes from the Intergenic Regions of Bacillus
subtilis
Dr. Richard Losick, Laboratory Sponsor
Rejoice Opara, (BCHM)
Biochemical and Structural Studies of the Bacillus Cereus
MCM-Primase N-Terminal Domain
Dr. David Jeruzalmi, Laboratory Sponsor
Jin Park, (BCHM)
Regulation of Neuronal Subtype Specification of Motor Neurons and
Midbrain Dopaminergic Neurons by bHLH factor Neurogenin2
Dr. Michael Greenberg, Laboratory Sponsor
Adam Xianpeng Sang, (BCHM) - Hoopes Prize
Zebrafish primordial germ cells require insulin-like growth factor
signaling for directional migration
Dr. Antony Wood, Laboratory Sponsor
Timothy Hunter Schmidt, (CPB)
Overclocking a Three-Protein Circadian Oscillator: Mutations in
KaiC in a Model of Ordered Phosphorylation
Dr. Erin O'Shea, Laboratory Sponsor
Lauren Maxine Snyder, (BCHM)
Confirmation and Characterization of the Human Cytomegalovirus UL27
Protein as an In Vitro Substrate of the UL97 Protein Kinase
Dr. Donald Coen, Laboratory Sponsor
Zachary Zhipeng Sun, (CPB)
Developing enabling technologies for high-throughput genomic
manipulation in Escherichia coli
Dr. George Church, Laboratory Sponsor
Jillian Sylvester, (BCHM)
Identification and Characterization of Novel S6 Kinase
Interactors
Dr. John Blenis, Laboratory Sponsor
Monica Thanawala, (BCHM)
Design, Construction, and Characterization of a Postsynaptic Marker
and Studies of Dystrophin Regulation in the Central Nervous System
of Drosophila melanogaster
Dr. Samuel Kunes, Laboratory Sponsor
Melissa Yuwono Tjota, (BCHM)
Peripheral Tissue Antigen and Cytokine Expression in Human
Mesenchymal Stem Cells and Murine Lymph Node Stromal Cells
Dr. Shannon Turley, Laboratory Sponsor
Tave Annamey van Zyl, (BCHM)
Asymmetric Catalytic Synthetic Studies and Biological Evaluation of
Peloruside A and Analogues
Dr. Eric Jacobsen, Laboratory Sponsor
Eunice Yang, (BCHM)
NPAS4 and the Critical Period Plasticity
Dr. Takao Hensch, Laboratory Sponsor
Jessica Yang, (BCHM)
Elucidating the mechanism of spreading of PRC2-mediated histone
methylation
Dr. Nicole Francis, Laboratory Sponsor
Darwin Yeung, (BCHM)
Developing a structural model of the rhesus monkey TRIM5α
coiled-coil domain and linker 2 region by comparative modeling and
mutation analysis.
Dr. Joseph Sodroski, Laboratory Sponsor
Alvin Yiu Chun Yu, (BCHM)
A novel model of vasculogenesis: Fluidic shear stress influences
endothelial differentiation of human embryonic stem cells
Dr. Debra Auguste, Laboratory Sponsor
Elisa T. Zhang, (MCB) - Hoopes Prize
Distinct sets of mRNA targets exhibit differential miRNA dose
responses
Dr. Tom Maniatis, Laboratory Sponsor
Ning Zhou, (BCHM)
Characterization of the Neuropathy of Mucopolysaccharidosis I in a
Murine Model
Dr. Jakub Tolar, Laboratory Sponsor
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