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2008 Undergraduate Honors Theses

submitted by Biochemical Sciences, Chemical and Physical Biology, and Molecular and Cellular Biology Concentrators

Michael Badgley, (BCHM)
Quantification of the magnitude of the hematopoietic stem cell (HSC) bone marrow niche and its possible applications
Dr. David Scadden, Laboratory Sponsor

Brandon Darwin Bartch, (BCHM)
The Role of the Groucho/transducin-like Enhancer-of-split Protein Family in the Mammalian Retina
Dr. Connie Cepko, Laboratory Sponsor

Michael Birnbaum, (CPB)
Synthesis and characterization of four putative kinase ligands discovered through DNA-templated synthesis based in vitro selections
Dr. David Liu, Laboratory Sponsor

Kelly Massiel Cadenas, (BCHM)
The Role of GlnA in Biofilm Formation by Bacillus subtilis
Dr. Richard Losick, Laboratory Sponsor

Joyce Chun-Ling Chang, (BCHM)
Targets of DNA damage response factors in B cells during class switch recombination
Dr. John Manis, Laboratory Sponsor

Serene Imperia Chen, (BCHM)
Synapse elimination provokes strengthening of the axonal inputs that innervate mouse submandibular ganglion neurons
Dr. Jeff Lichtman, Laboratory Sponsor

Daniel Choi, (BCHM)
Synthesis and Reactivity of Novel Organopalladium(IV) Fluoride Complexes
Dr. Tobias Ritter, Laboratory Sponsor

Ian Dennis Chong, (BCHM)
The Effect of WASp/WIP phosphorylation on Natural Killer Cell Cytotoxicity
Dr. Jack Strominger, Laboratory Sponsor

Jonathan Chow, (BCHM)
The Effect of HIV Infection on Proteasome Expression and Activity
Dr. Sylvie Le, Laboratory Sponsor

Katharine Rose Clapham, (BCHM) - Henderson Prize, Hoopes Prize
A tiny protein links two morphogenetic processes in a bacterium
Dr. Richard Losick, Laboratory Sponsor

Victoria Clark, (BCHM) - Hoopes Prize
Alternative Splicing Factor Sfrs10 Is Required for Terminal Differentiation of Rod Photoreceptor Outer Segments in the Mouse Retina
Dr. Connie Cepko, Laboratory Sponsor

Brandon Geller, (BCHM)
A first molecular phylogeny for the timber beetle family Cerambycidae; Relationships among Subfamilies
Dr. Brian Farrell, Laboratory Sponsor

Sharon Grossman, (CPB)
Predicting Expression Patterns from Promoter Sequences in the Saccharomyces Cerevisiae PHO Pathway
Dr. Erin O'Shea, Laboratory Sponsor

Lewis Dirk Hahn, (BCHM)
1. Development and Characterization of a Tat-based Gene Delivery System 2. Mediation of Gene Delivery of Lyophilized pDNA-polycation Complexes by Structure
Dr. David Mooney, Laboratory Sponsor

Madelyn Ho, (CPB)
Characterization of the role of microsomal triglyceride transfer protein in human CD1d-mediated antigen presentation
Dr. Richard Blumberg, Laboratory Sponsor

Jennifer W. Hsu, (BCHM)
Investigation of Lesions in TGF-β signaling pathways in Squamous Cell Carcinoma
Dr. James Rheinwald, Laboratory Sponsor

Supriya K. Jain, (BCHM)
Genetic Characterization of Colorectal Cancer Tumor-Initiating Cells
Dr. William Hahn, Laboratory Sponsor

Divya Jayaraman, (BCHM)
Development of a novel cell-free assay for detecting damage-induced single-stranded gaps in chromatin using Xenopus laevis egg extracts
Dr. Matthew Michael, Laboratory Sponsor

Gregory Alan Joice, (BCHM)
Characterization of Adult Zebrafish Renal Repair and the Role of FGF Signaling
Dr. Alan Davidson, Laboratory Sponsor

Michelle Minsun Jung, (BCHM)
Gene Expression Analysis of MLKB1KO Mice: Identifying a novel link between LKBI and the antioxidant GPX3
Dr. Laurie Goodyear, Laboratory Sponsor

Han Kim, (BCHM)
Synaptic Depression Following Postsynaptic Axotomy: Causes and Consequences
Dr. Jeff Lichtman, Laboratory Sponsor

Bong Ihn Koh, (BCHM)
Investigation of a Lymphatic Component to the Hematopoietic Stem Cell Microenvironment
Dr. David Scadden, Laboratory Sponsor

Richard R. Kronfol, (BCHM)
Acyl-Protein Thioesterase 1 and Modulation of Nitric Oxide Synthase
Dr. Thomas Michel, Laboratory Sponsor

Rachel Lefebvre, (BCHM) - Hoopes Prize
Molecular dissection of TGF-β induced signal transduction pathways controlling T-cell differentiation: I. Expression of inhibitor-resistant type I TGF-β receptors in T-cells reveals that inducible T regulatory cell development requires Smad activation. II. Quantitative analysis of Foxp3 and RORɣt gene expression during T-cell differentiation
Dr. Anjana Rao, Laboratory Sponsor

Yin Li, (BCHM)
FMRFamide-like Neuropeptides Modulate C. elegans Posture
Dr. Robert Horvitz, Laboratory Sponsor

Yuen-Joyce Liu, (BCHM)
Effect of Crohn’s disease associated mutations on the NOD2 signaling pathway
Dr. Koichi Kobayashi, Laboratory Sponsor

Eva Marie Luo, (BCHM)
Molecular Neuropathology of Aging: Characterization of Aging in the Caribbean Vervet
Dr. Cynthia Lemere, Laboratory Sponsor

Matthew R. McFarlane, (BCHM)
Analysis of Multiple cis-Regulatory Elements Governing a Graded Transcriptional Response of a Single Gene to a Mammalian Morphogen
Dr. Andrew McMahon, Laboratory Sponsor

Kevin McMullen, (BCHM)
Reproductive Survival and DNA Double-Strand Breakage in Desiccated Bdelloid Rotifer Adineta vaga
Dr. Matt Meselson, Laboratory Sponsor

Danny Mou, (BCHM) - Hoopes Prize
Edgetic-profiling of Disease-associated TP73L Mutant Proteins
Dr. Marc Vidal, Laboratory Sponsor

Melissa A. Mueller, (BCHM)
Involvement of Reactive Oxygen Species in Signaling Pathways Regulating Cisplatin-induced Death of Zebrafish (Danio rerio) Sensory Hair Cells
Dr. John Dowling, Laboratory Sponsor

Christopher Nabel, (BCHM)
Dynamics of Clathrin Coated Pit Formation at the Leading Edge of Migrating Cells
Dr. Tomas Kirchhausen, Laboratory Sponsor

Lachezar Atanasov Nikolov, (BCHM)
Discovery of New Genes from the Intergenic Regions of Bacillus subtilis
Dr. Richard Losick, Laboratory Sponsor

Rejoice Opara, (BCHM)
Biochemical and Structural Studies of the Bacillus Cereus MCM-Primase N-Terminal Domain
Dr. David Jeruzalmi, Laboratory Sponsor

Jin Park, (BCHM)
Regulation of Neuronal Subtype Specification of Motor Neurons and Midbrain Dopaminergic Neurons by bHLH factor Neurogenin2
Dr. Michael Greenberg, Laboratory Sponsor

Adam Xianpeng Sang, (BCHM) - Hoopes Prize
Zebrafish primordial germ cells require insulin-like growth factor signaling for directional migration
Dr. Antony Wood, Laboratory Sponsor

Timothy Hunter Schmidt, (CPB)
Overclocking a Three-Protein Circadian Oscillator: Mutations in KaiC in a Model of Ordered Phosphorylation
Dr. Erin O'Shea, Laboratory Sponsor

Lauren Maxine Snyder, (BCHM)
Confirmation and Characterization of the Human Cytomegalovirus UL27 Protein as an In Vitro Substrate of the UL97 Protein Kinase
Dr. Donald Coen, Laboratory Sponsor

Zachary Zhipeng Sun, (CPB)
Developing enabling technologies for high-throughput genomic manipulation in Escherichia coli
Dr. George Church, Laboratory Sponsor

Jillian Sylvester, (BCHM)
Identification and Characterization of Novel S6 Kinase Interactors
Dr. John Blenis, Laboratory Sponsor

Monica Thanawala, (BCHM)
Design, Construction, and Characterization of a Postsynaptic Marker and Studies of Dystrophin Regulation in the Central Nervous System of Drosophila melanogaster
Dr. Samuel Kunes, Laboratory Sponsor

Melissa Yuwono Tjota, (BCHM)
Peripheral Tissue Antigen and Cytokine Expression in Human Mesenchymal Stem Cells and Murine Lymph Node Stromal Cells
Dr. Shannon Turley, Laboratory Sponsor

Tave Annamey van Zyl, (BCHM)
Asymmetric Catalytic Synthetic Studies and Biological Evaluation of Peloruside A and Analogues
Dr. Eric Jacobsen, Laboratory Sponsor

Eunice Yang, (BCHM)
NPAS4 and the Critical Period Plasticity
Dr. Takao Hensch, Laboratory Sponsor

Jessica Yang, (BCHM)
Elucidating the mechanism of spreading of PRC2-mediated histone methylation
Dr. Nicole Francis, Laboratory Sponsor

Darwin Yeung, (BCHM)
Developing a structural model of the rhesus monkey TRIM5α coiled-coil domain and linker 2 region by comparative modeling and mutation analysis.
Dr. Joseph Sodroski, Laboratory Sponsor

Alvin Yiu Chun Yu, (BCHM)
A novel model of vasculogenesis: Fluidic shear stress influences endothelial differentiation of human embryonic stem cells
Dr. Debra Auguste, Laboratory Sponsor

Elisa T. Zhang, (MCB) - Hoopes Prize
Distinct sets of mRNA targets exhibit differential miRNA dose responses
Dr. Tom Maniatis, Laboratory Sponsor

Ning Zhou, (BCHM)
Characterization of the Neuropathy of Mucopolysaccharidosis I in a Murine Model
Dr. Jakub Tolar, Laboratory Sponsor