Electron microscopy is an ideal imaging technique to study biological cells at the nanoscale. However, conventional electron microscopy only provides static black-and-white images. In an effort to enable multicolor and time-resolved electron microscopy, our laboratory is developing dedicated molecular probes and instrumentation for new hybrid light and electron microscopy methods and building next-generation biophysical tools for time-resolved cryo-vitrification of biological structures across scales ranging from biomolecules in purified samples, to differentiated stem cells, primary cell cultures, and complex tissues. We are using these methods to investigate the nanoscale cellular organization of processes relevant to G protein-coupled receptor (GPCR) signaling, synaptic transmission in neurons, and microbial infections. Just like our research, our group is interdisciplinary and collaborative with every member constantly learning new concepts and skills. We are committed to recruiting and supporting trainees of diverse scientific and cultural backgrounds.