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Tag: Joshua Sanes

Putting Dendrites in the Right Place [Sanes Lab]

Dendrites are the antennae of neurons, receiving synaptic signals from other neurons. A critical aspect of wiring up complex neural circuits is to make sure that dendrites are…

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Scaling Up the Search for Neuronal Wiring Molecules [Sanes Lab]

Neural circuits in the mammalian brain comprise hundreds to millions of neurons, connected with each other in complex and highly specific ways. Studies over the past few decades…

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Turning the ON off: Sculpting One of Two Dendritic Branches in a Retinal Neuron [Sanes Lab]

The dendritic arbors of neurons are incredibly diverse in size and shape.  This makes sense, because dendritic morphology is a critical determinant of the numbers and types of…

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MCB Professor Wins Top Neuroscience Award

MCB professor Joshua Sanes has won this year’s Gruber Neuroscience Prize; a valuable international award given by the Society for Neuroscience and funded by Yale University’s Gruber Foundation.…

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MOLECULAR COMPETITION ENHANCES SYNAPTIC SPECIFICITY [SANES LAB]

As neurons develop in the central nervous system, they encounter many potential synaptic partners, and choose among them to form stable connections with only a few. The specific…

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STAMP COLLECTING GETS IMPORTANT [SANES LAB]

The complex circuits of the brain are built from thousands of types of neurons. More than a century ago, Santiago Ramon y Cajal founded what we now call…

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RECONSTRUCTION OF GENETICALLY IDENTIFIED NEURONS IMAGED BY SERIAL-SECTION ELECTRON MICROSCOPY [SANES AND LICHTMAN LABS]

Neurons connect with each other to form complex circuits that underlie mental activities. Mapping these connections to obtain a so-called wiring diagram is an essential step in learning…

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HOOKING UP TO DETECT LOCAL MOTION [SANES LAB]

The retina is not only a light sensor but also a sophisticated image processor. Photoreceptors (rods and cones) generate electrical signals when illuminated, much like pixels in a…

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JOSH SANES FEATURED IN SCIENCE MAGAZINE

Joshua Sanes contributes optimism (and a great deal of research) to an August 7 Science magazine article on the longstanding controversy of neuronal classification. While skeptics suspect we…

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THE ELEGANCE OF DENDRITES AND WHY IT MATTERS [SANES LAB]

Joshua Sanes (l) and Dimitar Kostadinov The dendritic processes of neurons form elaborate branched arbors that are stereotyped among neurons of a specific type but differ markedly among…

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