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Postdoctoral Fellow

Daniel Friedrich

Postdoctoral Fellow

Research

In the past, I established advanced magic angle spinning NMR methods to investigate protonation dynamics in proteins. Departing from this biophysical question, I am now interested in deciphering the fundamentals of protein–RNA interactions that play crucial roles in cellular biology, e.g. by controlling protein synthesis. Specifically, I aim to understand how intrinsically disordered protein regions, structural dynamics and RNA modifications are involved in orchestrating such complex cellular processes. To this end, I will be using structural biology and biophysical methods, in particular NMR spectroscopy, to gain insight into the underlying molecular mechanisms at atomic resolution. I will complement these findings by cell-based approaches to probe structure–function relationships in the cell. I thus aim to provide new information on RNA recognition by proteins, thereby contributing to extending our knowledge of how essential cellular processes are regulated.