Since my initial appointment as Assistant Professor at Harvard Medical School in 1983, I have been deeply involved in research and education. More than 120 individuals trained in my laboratory during the ensuing 35 years and most of those trainees have followed careers in science in both academic and industry settings. Research in the Kolter Lab has always gravitated around the study of microbes. We have explored a large number of different subjects ranging from basic bacterial physiology to bioactive compound discovery. In January of 2018 I became Professor Emeritus and I will soon close the laboratory. I will continue my involvement in science through teaching, writing and blogging in Small Things Considered.