Gaudet, Rachelle & Murray, Andrew
Indian Institute of Technology, Madras (Chemical Engineering)
A year ago, I walked away from being an engineer and entered the world of academia in Biology. In my time here, I have met and interacted with amazing scientists who have helped me identify and shape my interests. I enjoy the frequent ‘science chat’ with faculty and students alike and am fond of the journal clubs as great snippets of science in an informal setting. Outside of science, I collect comic books and relish my weekly trips to the bookstore with conversations on the latest events in the superhero multiverse. A year into a graduate school, I look forward to exploring the countryside, hiking and camping wherever possible.
I am fascinated by the ability of biological molecules to coordinate and execute their functions to maintain the cell in a non-equilibrium ‘living’ state. By virtue of my undergraduate training, I view these problems through the lenses of an engineer, trying to understand the operating characteristics and specifications of these machines. I am particularly interested in the machinery present at the cell membrane that is used to sense and respond to the cell’s environment. As part of my doctoral research, I plan to study an ATP-consuming pheromone transporter essential for mating in the budding yeast, Saccharomyces cerevisiae. The introductory graduate classes in genetics and cell biology at MCB gave me a new appreciation for the diversity of living systems across evolution. For my current project and in the future, I want to take advantage of phylogenetic variation and structural principles to understand the mechanistic basis of molecular machines.
Srikant S, Muralidharan SS, Natarajan U, Behavior of hydrogen bonding and structure of poly (acrylic acid) in water-ethanol solution investigated by explicit ion molecular dynamics simulations, Molecular Simulation. 2012.
Srikant S and Gsponer J (2010) ‘Transcript-level regulation, a codon-bias approach’ at the MITACS Globalink seminar.
Srikant S, Gaudet R and Murray A (2012) ‘Dissecting the mechanism of Ste6, an ABC transporter involved in Ste6 mating’ poster presented at the Dept. of MCB retreat