JEFF GELLES: "EXPLORING THE MECHANISM(S) OF PRE-MESSENGER RNA SPLICING" (CELLULAR DYNAMICS SEMINAR SERIES)
|Date/Time||Tue, 2/4/2014, 11:45 a.m. 1 p.m.|
|Location||16 Divinity Ave, Biolabs Lecture Hall, Room 1080|
|Description||"Exploring the mechanism(s) of pre-messenger RNA splicing"
Jeff Gelles, Ph.D.
Professor of Biochemistry
Splicing of pre-messenger RNAs is essential to the flow of genetic information in eukaryotes. Splicing is performed by the splicesome, a large molecular machine consisting of RNAs and >100 proteins that assembles anew for each splicing reaction. We have used multi-wavelength single-molecule fluorescence microscopy techniques to directly observe in real time the pathways and dynamics of spliceosome assembly and activation on individual pre-mRNA molecules. The observations reveal new features of these process that have implications for the mechanisms of splicing fidelity and splice site selection.
|(Center for Cellular Dynamics Details)|