Harvard University - Department of Molecular & Cellular Biology

JEFF GELLES: "EXPLORING THE MECHANISM(S) OF PRE-MESSENGER RNA SPLICING" (CELLULAR DYNAMICS SEMINAR SERIES)

Date/Time Tue, 2/4/2014, 11:45 a.m. – 1 p.m.
Location 16 Divinity Ave, Biolabs Lecture Hall, Room 1080
Description "Exploring the mechanism(s) of pre-messenger RNA splicing"

Jeff Gelles, Ph.D.
Professor of Biochemistry
Brandeis University
http://www.bio.brandeis.edu/~gelles/

Splicing of pre-messenger RNAs is essential to the flow of genetic information in eukaryotes. Splicing is performed by the splicesome, a large molecular machine consisting of RNAs and >100 proteins that assembles anew for each splicing reaction. We have used multi-wavelength single-molecule fluorescence microscopy techniques to directly observe in real time the pathways and dynamics of spliceosome assembly and activation on individual pre-mRNA molecules. The observations reveal new features of these process that have implications for the mechanisms of splicing fidelity and splice site selection.
  (Center for Cellular Dynamics Details)
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