Harvard University - Department of Molecular & Cellular Biology

SEAN G. MEGASON: "IN TOTO IMAGING REVEALS HOW DEVELOPMENTAL NOISE IS CANALIZED IN NEURAL TUBE PATTERNING" (CELLULAR DYNAMICS SEMINAR SERIES)

Date/Time Tue, 9/24/2013, 11:45 a.m. – 1 p.m.
Location 16 Divinity Ave, Biolabs Lecture Hall, Room 1080
Description "In toto imaging reveals how developmental noise is canalized in neural tube patterning"

Sean G. Megason, Ph.D.
Assistant Professor, Department of Systems Biology
Harvard Medical School
https://sysbio.med.harvard.edu/faculty/megason/

Abstract: Embryos robustly control their growth and form to generate structures of precise pattern, size, shape, and symmetry. How do developmental systems achieve such macroscopic precision using molecular programs which are inherently noisy? Using in toto imaging of the neural tube in developing zebrafish embryos, we find that noise originating from both molecular and cellular levels constrains the precision of positional information. We further show that this noise is canalized by the higher-scale mechanism of cell sorting to generate proper pattern formation. Two additional examples from the inner ear and embryonic skin also reveal noise at molecular and cellular scales that is regulated by higher-scale physical mechanisms.
  (Center for Cellular Dynamics Details)
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