Harvard University - Department of Molecular & Cellular Biology

PAUL CHANG: "NEW PARP FUNCTIONS IN MRNA AND PROTEIN HOMEOSTASIS" (CELLULAR DYNAMICS SEMINAR SERIES)

Date/Time Tue, 11/19/2013, 11:45 a.m. – 1 p.m.
Location 16 Divinity Ave, Biolabs Lecture Hall, Room 1080
Description "New PARP Functions in mRNA and protein homeostasis"

Paul Chang, Ph.D.
Assistant Professor
Koch Institute for Integrative Cancer Research and Department of Biology
Massachusetts Institute of Technology
http://web.mit.edu/ki/labs/chang/index.html

Abstract: The general focus of my laboratory is to understand the function of the poly(ADP-ribose) polymerase (PARP) family of proteins. These proteins are responsible for ADP-ribosylation of target proteins using NAD+ as substrate. ADP-ribosylation alters the function of target proteins via covalent modification. In addition some PARPs generate a longer polymer called poly(ADP-ribose) (PAR) that acts as a scaffold for recruitment of ADP-ribose binding proteins. During my talk I will discuss two PARP functions discovered in my laboratory, post-transcriptonal regulation of mRNAs, and regulation of the unfolded protein response.
  (Center for Cellular Dynamics Details)
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