PAUL CHANG: "NEW PARP FUNCTIONS IN MRNA AND PROTEIN HOMEOSTASIS" (CELLULAR DYNAMICS SEMINAR SERIES)
|Date/Time||Tue, 11/19/2013, 11:45 a.m. 1 p.m.|
|Location||16 Divinity Ave, Biolabs Lecture Hall, Room 1080|
|Description||"New PARP Functions in mRNA and protein homeostasis"
Paul Chang, Ph.D.
Koch Institute for Integrative Cancer Research and Department of Biology
Massachusetts Institute of Technology
Abstract: The general focus of my laboratory is to understand the function of the poly(ADP-ribose) polymerase (PARP) family of proteins. These proteins are responsible for ADP-ribosylation of target proteins using NAD+ as substrate. ADP-ribosylation alters the function of target proteins via covalent modification. In addition some PARPs generate a longer polymer called poly(ADP-ribose) (PAR) that acts as a scaffold for recruitment of ADP-ribose binding proteins. During my talk I will discuss two PARP functions discovered in my laboratory, post-transcriptonal regulation of mRNAs, and regulation of the unfolded protein response.
|(Center for Cellular Dynamics Details)|