Harvard University - Department of Molecular & Cellular Biology

FRANCES H. ARNOLD: "NEW ENZYMES BY EVOLUTION: EXPANDING NATURES CATALYTIC REPERTOIRE" (MCB EDSALL LECTURE)

Date/Time Thu, 4/17/2014, noon – 1 p.m.
Location NW Lecture Hall B-103 (52 Oxford St.)
Description "New Enzymes by Evolution: Expanding Natures Catalytic Repertoire"

Frances H. Arnold, Ph.D.
Dickinson Professor of Chemical Engineering, Biochemistry and Bioengineering
Director, Ben and Donna Rosen Bioengineering Center
California Institute of Technology
http://www.che.caltech.edu/groups/fha/

Abstract:
Enzymes are admired for their ability to selectively catalyze myriad transformations. We use laboratory evolution experiments to understand better how evolution modifies existing enzymes and creates new ones. A powerful approach to engineering biological molecules, directed evolution both circumvents and underscores our profound ignorance of how sequence encodes catalytic function. I will describe how we have used evolution (contaminated with a little chemical intuition) to generate new enzymes starting from one of natures most impressive, the cytochrome P450 monooxygenase.
  (Molecular & Cellular Biology)
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