FRANCES H. ARNOLD: "NEW ENZYMES BY EVOLUTION: EXPANDING NATURES CATALYTIC REPERTOIRE" (MCB EDSALL LECTURE)
|Date/Time||Thu, 4/17/2014, noon 1 p.m.|
|Location||NW Lecture Hall B-103 (52 Oxford St.)|
|Description||"New Enzymes by Evolution: Expanding Natures Catalytic Repertoire"
Frances H. Arnold, Ph.D.
Dickinson Professor of Chemical Engineering, Biochemistry and Bioengineering
Director, Ben and Donna Rosen Bioengineering Center
California Institute of Technology
Enzymes are admired for their ability to selectively catalyze myriad transformations. We use laboratory evolution experiments to understand better how evolution modifies existing enzymes and creates new ones. A powerful approach to engineering biological molecules, directed evolution both circumvents and underscores our profound ignorance of how sequence encodes catalytic function. I will describe how we have used evolution (contaminated with a little chemical intuition) to generate new enzymes starting from one of natures most impressive, the cytochrome P450 monooxygenase.
|(Molecular & Cellular Biology)|