Harvard University - Department of Molecular & Cellular Biology

VLAD DENIC

Denic
Associate Professor of Molecular and Cellular Biology

Email: vdenic@mcb.harvard.edu
Phone: 617-496-6381

Mail: NW 445.30
Northwest Building
52 Oxford St
Cambridge, MA  02138

Denic Lab Homepage
Members of the Denic Lab
List of Publications from PubMed

Courses

MCB 60. Cellular Biology and Molecular Medicine
Catalog Number: 35967  View Course Website
Term: Fall Term 2014-2015.
Instructors: Briana Burton, Vladimir Denic, Alexander Schier
Course Level: Primarily for Undergraduates
Description: This course provides an introduction to the principles of molecular and cellular biology and their connections to biomedicine. We explore how medical syndromes provide insights into biological processes and how biological mechanisms underlie human disease and physiology. Topics range from DNA repair, protein folding and vesicle transport to metabolism, cell migration and cancer. Lectures focus on the experimental evidence for key concepts, and the weekly sections combine a discovery-based laboratory research project with discussions that emphasize problem solving and primary literature.
Prerequisite(s): LPS A or LS 1a, LS 1b recommended.
Meetings: M., W., F., at 10
MCB 155. Bioregulatory Mechanisms
Catalog Number: 6230  View Course Website
Term: [Spring Term .]
Instructor: Vladimir Denic
Course Level: For Undergraduates and Graduates
Description: An advanced course that emphasizes the scientific logic and technical innovations behind the discoveries of certain well-established cell and molecular mechanisms. Topics will include nuclear transport, ribosomal protein synthesis, protein folding, protein targeting to membranes, and protein degradation. The course will be taught by combining lecture material with student presentations and criticism of seminal papers with emphasis on experimental design, the importance of complementary in vivo and in vitro systems, and defining unanswered questions in the field.
Prerequisite(s): MCB 60 or MCB 52 and MCB 54, and permission of instructor.
Meetings: Tu., Th., 4-6
MCB 290hfr. Current Topics in Molecular, Cellular and Organismal Biology
Catalog Number: 31903  View Course Website
Term: Fall Term And Spring Term 2014-2015.
Instructor: Vladimir Denic
Course Level: Primarily for Graduates
Description: This class teaches students how to publicly present scientific papers to a diverse audience with emphasis on contextualizing the scientific problem under discussion, critically presenting the essential data, and using an engaging presentation style.
Note: Required for all first and second year graduate students in the Molecules, Cells and Organisms (MCO) Training Program. This course must be taken Sat/Unsat.
Meetings: F., at 3:30
BIOPHYS 322. Structural Diversification of Very Long-Chain Fatty Acids
Catalog Number: 67039  View Course Website
Term: Fall Term And Spring Term 2014-2015.
Instructor: Vladimir Denic
Course Level: Exclusively for Graduates
(View all MCB Courses)

Research

The application of novel methodologies for studying biology at a genome-wide level has been a remarkably successful means of cataloging the components required for many cellular processes. At the same time, however, this has created a bottleneck at the level of going from parts lists to functional and mechanistic insights. Nowhere is this more apparent than in the study of membrane-associated processes. This area of cell biology has been particularly difficult to dissect by classical biochemistry but now stands poised to benefit from targeted and systematic biochemical reconstitution strategies that make use of the identified components. My lab is interested in bridging this post-genomic gap as it pertains to the study of very long-chain fatty acids, insertion of tail-anchored proteins into the endoplasmic reticulum membrane, and autophagy.

Publications

Schuldiner M., Metz J., Schmid V., Denic V. et al. (2008), The Get Complex Mediates Insertion of Tail-Anchored Proteins into the ER. Cell; 134, 634-45.

Denic V., Weissman J. S. (2007) A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length. Cell; 130, 663-677

Denic V., Quan E.M., and Weissman, J. S. (2006) A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for Endoplasmic Reticulum-Associated Degradation. Cell; 126, 349-359.

Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V. et al. (2005) Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile. Cell; 123, 507-519

Bhamidipati, A., Denic, V., Quan, E. M., and Weissman, J. S. (2005). Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER lumen. Molecular Cell; 19, 741-751.

updated: 07/28/2015