Mail: NW 445.30
52 Oxford St
Cambridge, MA 02138
Denic Lab Homepage
Members of the Denic Lab
List of Publications from PubMed
Term: Spring Term 2013-2014. Credit: Half course.
Instructors: Vladimir Denic, Robert Lue
Course Level: Primarily for Undergraduates
Description: An integrated introduction to the structure, function, and interactions of cells. Topics covered include: membrane structure and transport, receptors and channels, protein targeting, cytoskeleton, cell cycle, signal transduction, cell migration, cell growth and death, cell adhesion, cell polarity, embryogenesis, organogenesis, and stem cells.
Note: Laboratory and discussion sessions focus on problem solving and evaluation of data. A series of linked laboratory exercises provides exposure to several techniques commonly used in cell biology and developmental biology. This course, when taken for a letter grade, meets the General Education requirement for Science of Living Systems or the Core area requirement for Science B.
Prerequisite(s): Life and Physical Sciences A or Life Sciences 1a; Life Sciences 1b recommended.
Meetings: M., W., F., at 10, and one laboratory/discussion session weekly.
Term: Full Year 2013-2014. Credit: Half course.
Instructor: Vladimir Denic
Course Level: Primarily for Graduates
Description: This class teaches students how to publicly present scientific papers to a diverse audience with emphasis on contextualizing the scientific problem under discussion, critically presenting the essential data, and using an engaging presentation style.
Note: Required for all first and second year graduate students in the Molecules, Cells and Organisms (MCO) Training Program. This course must be taken Sat/Unsat.
Meetings: F., at 3:30
Term: Fall Term; Repeated Spring Term 2013-2014. Credit: Half course.
Instructor: Vladimir Denic
Course Level: Graduate Course
The application of novel methodologies for studying biology at a genome-wide level has been a remarkably successful means of cataloging the components required for many cellular processes. At the same time, however, this has created a bottleneck at the level of going from parts lists to functional and mechanistic insights. Nowhere is this more apparent than in the study of membrane-associated processes. This area of cell biology has been particularly difficult to dissect by classical biochemistry but now stands poised to benefit from targeted and systematic biochemical reconstitution strategies that make use of the identified components. My lab is interested in bridging this post-genomic gap as it pertains to the study of very long-chain fatty acids, insertion of tail-anchored proteins into the endoplasmic reticulum membrane, and autophagy.
Schuldiner M., Metz J., Schmid V., Denic V. et al. (2008), The Get Complex Mediates Insertion of Tail-Anchored Proteins into the ER. Cell; 134, 634-45.
Denic V., Weissman J. S. (2007) A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length. Cell; 130, 663-677
Denic V., Quan E.M., and Weissman, J. S. (2006) A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for Endoplasmic Reticulum-Associated Degradation. Cell; 126, 349-359.
Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V. et al. (2005) Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile. Cell; 123, 507-519
Bhamidipati, A., Denic, V., Quan, E. M., and Weissman, J. S. (2005). Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER lumen. Molecular Cell; 19, 741-751.