Harvard University - Department of Molecular & Cellular Biology

MODEL OF THE ATP-DEPENDENT CHROMATIN REMODELING COMPLEX RSC BOUND TO A NUCLEOSOME

Source: Leschziner Lab

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"ATP-dependent chromatin remodeling complexes utilize the energy from ATP hydrolysis to non-covalently alter the structure of nucleosomes. We are interested in understanding the mechanistic basis of this remodeling activity. We have obtained an initial reconstruction of RSC, an ATP-dependent chromatin remodeling complex from S.cerevisiae using electron microscopy and single-particle approaches. A micrograph is shown in the background and RSC in grey. The complex has a large central cavity showing a striking surface complementarity with a nucleosome (modeled in yellow), suggesting this might be the binding site for its substrate."

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updated: 04/15/2014