Harvard University - Department of Molecular & Cellular Biology

GABA NEURONS CONTROLLING BRAIN PLASTICITY

Source: Hensch Lab

Gallery Image

Fast-spiking GABA neurons coordinate critical periods of circuit refinement in the early postnatal neocortex. Otx2 homeoproteins (red) control the maturational state of these pivotal cells, which acquire a peri-neuronal net (blue) that limits plasticity with age. This parvalbumin network is particularly vulnerable in mental disorders.

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updated: 04/15/2014