GABA NEURONS CONTROLLING BRAIN PLASTICITY
Source: Hensch Lab
Fast-spiking GABA neurons coordinate critical periods of circuit refinement in the early postnatal neocortex. Otx2 homeoproteins (red) control the maturational state of these pivotal cells, which acquire a peri-neuronal net (blue) that limits plasticity with age. This parvalbumin network is particularly vulnerable in mental disorders.