Harvard University - Department of Molecular & Cellular Biology

NMR STRUCTURE ENSEMBLE OF THE MURINE LEUKEMIA VIRUS MRNA READ-THROUGH PSEUDOKNOT

Source: D'Souza Lab

Gallery Image

The MLV pseudoknot is protonated at A17 (red) to induce formation of the active structure in which loop 2 (green) engages the RNA double-helix (blue and grey) in a regulated proportion of mRNA molecules. The distribution correlates with the recoding frequency observed in vivo, providing a mechanism for read-through stimulation.

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updated: 04/15/2014