Harvard University - Department of Molecular & Cellular Biology

RNAI DEPLETION OF PLK1 BLOCKS ANAPHASE

Source: Erikson Lab

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"The protein kinase, Plk1, concentrates on the central spindle during anaphase in mammalian cells. (A. Mol Cell Biol., 1995, 15, 7143; Oncogene, 2004, 23, 763).

RNAi depletion of Plk1 blocks anaphase completion with unseparated chromosomes. (B. PNAS, 2002, 99, 8672).

RNAi depletion of NudC (C. Dev Cell, 2003, 5, 127) and MKLP1 (D), two Plk1 substrates, induces chromosomes lagging (C) and cytokinesis failure (D)."

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updated: 04/22/2014