Harvard University - Department of Molecular & Cellular Biology

CRYSTAL STRUCTURE OF A TAP CYTOSOLIC DOMAIN WITH ATP

Source: Gaudet Lab

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The TAP transporter uses the energy from ATP binding and hydrolysis to pump short peptides from the cytosol into the endoplasmic reticulum. These peptides are then loaded on class I MHC molecules and presented to the immune system for detecting virus infection or cancer. The Gaudet lab uses a combination of structure determination and biochemistry to understand how TAP undergoes important conformational changes during a catalytic cycle.

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updated: 04/22/2014