CRYSTAL STRUCTURE OF A TAP CYTOSOLIC DOMAIN WITH ATP
Source: Gaudet Lab
The TAP transporter uses the energy from ATP binding and hydrolysis to pump short peptides from the cytosol into the endoplasmic reticulum. These peptides are then loaded on class I MHC molecules and presented to the immune system for detecting virus infection or cancer. The Gaudet lab uses a combination of structure determination and biochemistry to understand how TAP undergoes important conformational changes during a catalytic cycle.