Harvard University - Department of Molecular & Cellular Biology

MCB NEWS TAG: 'PUBLICATION'

156 stories listed
Look Mom, No Breaks! [Kleckner Lab] - April 4, 2014
Chromosomal regions of identical or nearly identical DNA sequence can ...
Transparent Thoughts [Engert Lab] - March 19, 2014
How do brains process sensory input and use these to ...
Moving Like a Toddler [Schier Lab] - Jan. 9, 2014
According to the British embryologist Lewis Wolpert, “it is not ...
A Master Regulator for Circadian Gene Expression [O'Shea Lab] - Dec. 20, 2013
Organisms from humans to bacteria utilize endogenous timing mechanisms called ...
MCB News Tags:  2013, Cell, Erin O'Shea, publication
What Does it Take to be Sexy? [Murray Lab] - Dec. 4, 2013
There are two answers to this question, the master regulators ...
Bacteria Remember the Past when Deciding about the Future [Losick Lab] - Nov. 20, 2013
Bacillus subtilis is a bacterium with many talents. Some cells ...
SWR1 [Leschziner Lab] - Sept. 12, 2013
Genome packaging is a universal process in eukaryotes. In the ...
Morphogen Gradients, Non-Coding RNAs, and Multicolored Fish [Schier Lab] - July 11, 2013
In three papers published in Development, the Schier lab suggests ...
Body Building in E. coli [Berg Lab] - July 2, 2013
Contact with a surface is believed to trigger bacterial swarmer-cell ...
MCB News Tags:  2013, Howard Berg, PNAS, publication
The Life of an Axon [Sanes Lab] - June 24, 2013
Neurons send signals to other neurons along axons. Their growth ...
MCB News Tags:  2013, Joshua Sanes, Neuron, publication
Cracking the Temporal Code for Smell using Light [Murthy and Uchida Labs] - June 14, 2013
When we sniff an odor, it is first detected by ...
Brainbow 2.0 [Lichtman and Sanes Labs] - May 24, 2013
In 2007, the labs of Professors Jeff Lichtman and Josh ...
MCB News Tags:  2013, Nature Methods, publication
Robust Clocks in Growing Bacteria [O'Shea Lab] - May 10, 2013
Living organisms tightly coordinate their physiology with the day and ...
MCB News Tags:  2013, Erin O'Shea, publication, Science
How Does E. coli Segregate Its Sisters without a Spindle? [Kleckner Lab] - April 26, 2013
The E. coli chromosome is a single circular unit which ...
MCB News Tags:  2013, Cell, Nancy Kleckner, publication
Working Hard or Hardly Working? [Uchida Lab] - April 15, 2013
How many decisions did you have to make today? From ...
It's Not You, It's Me [Sanes Lab] - July 30, 2012
Neurons in the brain extend elaborately branched dendrites that receive ...
MCB News Tags:  2012, Joshua Sanes, Nature, publication
Good Noise, Bad Noise [Uchida Lab] - July 18, 2012
Biological systems are inherently noisy: they contain randomness beyond an ...
Predicting Bacteria's Response to Multidrug Treatment [Cluzel Lab] - July 10, 2012
Severe microbial infections, such as tuberculosis and MRSA, often require ...
Volume Control at the Synapse [Murthy Lab] - June 22, 2012
You can't miss it in the news these days ...
The Inputome of Dopamine Neurons Identified [Uchida Lab] - June 7, 2012
A central goal in neuroscience is to understand how diverse ...
Study Suggests Neural Wiring Peaks at Birth and Then it's All Downhill from There [Lichtman Lab] - June 7, 2012
The goal of this study was to investigate the pattern ...
MCB News Tags:  2012, Jeff Lichtman, Neuron, publication
Fish in the Matrix: Motor Learning in a Virtual World - May 11, 2012
There are two fundamentally different forms of sensory information that ...
More Tricks in Bacterial Chemotaxis - April 17, 2012
The bacteriumEscherichia colidecides whether life is getting better or worse ...
MCB News Tags:  2012, Howard Berg, Nature, publication
Reaction-Diffusion Patterning in Development - April 12, 2012
How do zebras get their stripes and leopards their spots ...
Spreading the Wealth in the Retina - March 22, 2012
The retina is a lot more complicated than a simple ...
MCB News Tags:  2012, Joshua Sanes, Nature, publication
Dissecting Computation in the Dopamine Reward Circuit - Jan. 18, 2012
In 1954, Olds and Milner discovered that direct, electrical stimulation ...
Keeping the Faith: The Final Act of Stopping Careless Cells - Jan. 3, 2012
Faithful chromosome segregation during cell division keeps cells alive and ...
Retroviral RNA Snaps into Shape! - Dec. 1, 2011
Retroviruses, like all viruses, rely on host protein machinery to ...
Special Delivery for RNA Silencing - Nov. 21, 2011
A powerful way to treat genetic diseases and combat viral ...
Smell Your Friends from Your Enemies! - Oct. 5, 2011
Unlike humans, most animals rely heavily on scents to collect ...
How to Shuck a Specialized Chaperone - Sept. 9, 2011
Eukaryotic cells target a large fraction of proteins synthesized in ...
Sculpting Sound Space in the Developing Brain - Aug. 12, 2011
Brain functions, such as language, are shaped by experience during ...
Sticking Together Makes Life Sweeter - Aug. 9, 2011
Gene expression is controlled by a class of proteins called ...
CisCode, Trans Effect, Transcription Specificity - June 27, 2011
Gene expression is controlled by a class of proteins called ...
How do Pluripotent Cells Choose a Fate? - June 10, 2011
A fundamental question in developmental biology is how multi-potent cells ...
Bacterial Circadian Clocks Tightly Linked to Metabolism - Jan. 25, 2011
Circadian clocks are biological oscillators that help organisms keep track ...
MCB News Tags:  2011, Erin O'Shea, publication, Science
The Brain Unplugged - Jan. 19, 2011
At least since the 1950s studies of sensory systems have ...
Changing the Culture of Science Education at Research Universities - Jan. 14, 2011
Professors at large research universities have two important responsibilities: generating ...
How to Infer Cellular Response to a Small Stimulus from Behavioral Variability before Stimulus in Bacteria - Jan. 14, 2011
Over the last decade, there have been a string of ...
Resolving the Molecular Architecture of Synapses using Light Microscopy - Dec. 17, 2010
Synapses are highly specialized junctions between neurons that are the ...
MCB News Tags:  2010, Neuron, publication
Removing an Endogenous Prototoxin Restores Vision - Dec. 9, 2010
Much of our behavior reflects the neural circuits sculpted by ...
MCB News Tags:  2010, publication, Science, Takao Hensch
How to Find Your Homolog Without Losing Your Sister - Dec. 9, 2010
Meiosis is a modified cellular program by which a single ...
MCB News Tags:  2010, Cell, Nancy Kleckner, publication
Sniffing Out the Odor Code: A Role for Spike Timing - Nov. 3, 2010
How would you describe the smell of fresh baked bread ...
Mice that Smell Light - Oct. 18, 2010
Olfaction is a critical sense for many animals, guiding their ...
The Moving Parts of a Tail-Anchored Protein Sorting Machine - Sept. 20, 2010
Membrane protein targeting is a fundamental problem in cell biology ...
Exercise, Caloric Restriction Rejuvenate Aging Synapses - Aug. 2, 2010
Harvard researchers have uncovered a mechanism through which caloric restriction ...
Parental Conflicts in the Brain - July 8, 2010
Parents influence the brain development and the behavior of their ...
MCB News Tags:  2010, Catherine Dulac, publication
A Small Molecule Trigger for Biofilm Disassembly - May 7, 2010
A three-way collaboration between the laboratories of Rich Losick in ...
Molecular Mechanics of Hearing and Deafness - April 15, 2010
Our senses are essential for survival and for the exploration ...
The Chromatin Signature of Pluripotent Cells - March 24, 2010
The genomes of most animals are inactive for hours or ...
Modulating the Catalytic Activity of a Protein Phosphatase by Externally-imposed Force - Feb. 19, 2010
There is widespread current interest in the roles of mechanical ...
Predicting Drug Targets by Watching Zebrafish Sleep - Jan. 14, 2010
Many psychiatric drugs were discovered decades ago through serendipity. For ...
Marvels of Bacterial Swarming - Jan. 13, 2010
When grown on a rich medium on agar, many bacteria ...
A Role for microRNAs in Amyotrophic Lateral Sclerosis - Dec. 12, 2009
The great baseball player, Lou Gehrig, gave his name to ...
MCB News Tags:  2009, Joshua Sanes, publication, Science
GABA Neurons Turn a Blind Eye - Nov. 16, 2009
A new study, published in this week’s Nature, that ...
MCB News Tags:  2009, Nature, publication, Takao Hensch
Optogenetics in India - Sept. 1, 2009
As a part of the Harvard-Bangalore Science Initiative (HSBI), Prof ...
Serotonin and Smell - May 27, 2009
A moment’s introspection reveals that our perceptions and actions ...
Emeritus MCB Professor “Untangles” the Double Helix in New Book - May 4, 2009
James C. Wang, the emeritus Mallinckrodt Professor of Biochemistry and ...
Visual Space within a Dendrite - March 25, 2009
More than a century ago, famous neuroanatomist and histologist Ramon ...
Evolution and Specificity of MAP Kinases - March 23, 2009
During evolution certain gene families have increased in number following ...
Geometric Cue for Protein Localization - March 6, 2009
Although bacteria are much more architecturally simple than eukaryotic cells ...
A Structural Model for the DNA Damage Sensor in Bacterial Nucleotide Excision Repair - March 5, 2009
Genomic DNA is under a constant attack by various damaging ...
Connectomics - Feb. 12, 2009
It is widely believed that in order to understand how ...
Silent Communication - Jan. 29, 2009
Distant cells in our body talk to each other to ...
Charting Olfaction - Jan. 19, 2009
Our brains generally represent the outside world using ordered maps ...
How Not to Wear Out a Welcome - Dec. 12, 2008
Just as dinner party guests who linger at the table ...
Wnts on the Brain: Requirement of Wnt Signaling in CNS Vasculature Development - Dec. 10, 2008
All tissues in our bodies require blood vessels for oxygen ...
Dissecting Transcriptional Network Structure and Function - Nov. 19, 2008
The gene expression program in a cell is set in ...
A Quantitative Model of Transcription Factor–activated Gene Expression - Oct. 27, 2008
One of the main challenges in the postgenomic era is ...
Decoding Regulatory Circuitry in Mammalian Limb Development - Oct. 10, 2008
The vertebrate limb has been one of the central models ...
Perceiving Smells with Sparse Connections - Sept. 11, 2008
Many regions of the brain are organized in such a ...
Engineering Binocularity in the Zebrafish Brain - Sept. 9, 2008
A major outstanding question in neurobiology is how the brain ...
Trigger for Brain Plasticity Identified - Aug. 8, 2008
Researchers have long sought a factor that can trigger the ...
MCB News Tags:  2008, Cell, publication, Takao Hensch
Self-renewal in the Kidney: A Developing Story - Aug. 7, 2008
The kidney is a remarkable organ. Its actions maintain an ...
Piggy-backing Meiotic Chromosomes - June 27, 2008
Movement plays important fundamental roles in basic chromosomal processes. Motion ...
MCB News Tags:  2008, Cell, Nancy Kleckner, publication
Watching Synapses Change in Animals - June 26, 2008
It is widely assumed that alterations in synaptic connections between ...
Astrocytes Spy on Neuronal Conversation to Bring a Rush of Blood to the Head - June 25, 2008
The human brain represents approximately 2% of the total body ...
A Common Aquatic Animal's Genome can Capture Foreign DNA - May 29, 2008
Long viewed as straitlaced spinsters, sexless freshwater invertebrate animals known ...
Chromatin — A One-Stop Engineering Solution for Compacting DNA and Parameterizing Gene Behavior - April 24, 2008
If stretched end-to-end, the DNA inside a single human cell ...
MCB News Tags:  2008, Erin O'Shea, Nature, publication
Small but Mighty - April 3, 2008
In a behaving animal, the brain processes information from sensory ...
A Neural Code Based on Spike Timing in the Retina - April 2, 2008
The process of vision begins in the retina. This neuronal ...
What's "Up" with Mouse Vision? - March 27, 2008
A mouse is small, close to the ground. Hawks and ...
Dulac Lab: Small RNAs and the Sense of Smell - Jan. 22, 2008
Modern genetics textbooks highlight the concept of the ‘central dogma ...
Meister Lab: The Eye Has a Short Attention Span - Nov. 28, 2007
No matter how hard we fix our gaze, our eyes ...
Technicolor Brains: Mapping Neural Circuits in "Brainbow" Mice - Nov. 28, 2007
In a paper published in the November 1 issue of ...
Gelbart Lab: Genome Analysis of Twelve Drosophila Species - Nov. 8, 2007
On Thursday, November 8, there was a birth announcement that ...
Multisite Phosphorylation and Circadian Oscillations - Oct. 17, 2007
Michael Rust and Joe Markson, a postdoc and graduate student ...
MCB News Tags:  2007, Erin O'Shea, publication, Science
MicroRNAs and Nodal Signaling - Aug. 31, 2007
Choi et al. developed a technology to block the interaction ...
Gaining Strength From Inactivity - Aug. 30, 2007
Perhaps you have had the experience of walking into a ...
Female and Male Mice Sexual Behaviors are Just a Sniff Away - Aug. 29, 2007
In a set of experiments published in the August 5th ...
Switching on Brain-Specific Alternative Splicing with a microRNA - Aug. 7, 2007
In an exciting breakthrough the Maniatis lab has now identified ...
Giving Hedgehog the Gas: Identification of Gas1 as a Novel Positive Component of Shh Signaling - July 20, 2007
In the May 15th issue of Genes & Development, Allen et ...
Fine-tuning Heat Sensitivity - June 26, 2007
Everyone has felt burning pain sensations, whether it was from ...
Embryonic Stem Cells and Cloned Animals Produced by Chromosome Transfer into Mouse Zygotes - June 14, 2007
Our lab sought other cell types besides oocytes that might ...
MCB News Tags:  2007, Kevin Eggan, Nature, publication
Turning Back the Developmental Clock: Directly Reprogrammed Fibroblasts Indistinguishable from Embryonic Stem Cells - June 11, 2007
Nuclear transfer experiments, such as the cloning of Dolly the ...
MCB News Tags:  2007, Cell Stem Cell, publication
Chipping Away at Hedgehog-Mediated Neural Patterning - May 18, 2007
The Hedgehog signaling pathway represents one of approximately six major ...
A Kinase Pathway Required for Neuronal Polarity - May 4, 2007
Proper polarization of neurons during development is essential for circuit ...
MCB News Tags:  2007, Cell, Joshua Sanes, publication
Neurodegeneration in a Petri-Dish: An Embryonic Stem Cell Model for ALS - April 24, 2007
This publication (authored by DiGiorgio, Carrasco, Siao, Maniatis and Eggan ...
MCB News Tags:  2007, Kevin Eggan, Nature, publication
Regulation of Cyclin-CDK Activity by Inositol Pyrophosphates - April 20, 2007
Lee et al. recently defined a new role for the ...
MCB News Tags:  2007, publication, Science
Target-Derived Signals Organize Motor Nerve Terminals - April 5, 2007
Using the neuromuscular junction, an accessible, peripheral synapse between a ...
MCB News Tags:  2007, Cell, Joshua Sanes, publication
Retinal Ganglion Cells Rapidly Change Polarity - April 2, 2007
Different neurons are tuned to different features, for example some ...
Putting a Face on a Class of Viral Deubiquitinating Enzymes - March 12, 2007
Members of the Gaudet and Ploegh labs teamed up and ...
Yanking the Chain: Pulling on Bacterial Flagella to Trigger Polymorphic Transformations - March 6, 2007
In many of the bacteria that swim by rotating helical ...
Ikβ Kinase IKKε Plays Critical Role in Antiviral Innate Immunity - March 5, 2007
Previous work from our lab identified two functionally redundant kinases ...
MCB News Tags:  2007, publication, Science, Tom Maniatis
New Light on Bioluminescence Evolution - Jan. 22, 2007
The evolution of genes for light emission might have involved ...
Sleeping With the Fishes - Dec. 21, 2006
Although we spend a third of our life asleep, it ...
Pro Antibodies - Nov. 29, 2006
In a paper appearing in the November 28, 2006 issue ...
TAP's Two-Cylinder Engine - Oct. 6, 2006
Our experiments looked at the "engine" part of TAP, or ...
Switching off a Cell Cycle Checkpoint - Aug. 7, 2006
Cell cycle checkpoints are surveillance mechanisms that ensure the ordered ...
Bad to the Bone: Unlocking the Molecular Regulation of Osteoblast Differentiation and Bone Synthesis - July 27, 2006
Bone can be produced by two distinct mechanisms: direct differentiation ...
Mapping Evolution: Linking Adaptive Traits to Genomic Location - July 25, 2006
Life exists in an impressive variety of forms, but the ...
Mammalian Egg Progenitors Stay Put - July 7, 2006
Recent reports have suggested that the mouse ovary might have ...
MCB News Tags:  2006, Kevin Eggan, Nature, publication
Natural Killers Have a Complex - June 19, 2006
In our recent study (Krzewski et al., J Cell Biol ...
Translating the Language of Pheromones - June 1, 2006
When animals meet, how do they distinguish friend from foe ...
Splitting Hedgehog - May 10, 2006
In their latest work, published in the journal Developmental Cell ...
Clues to Sonic Hedgehog's Behavior - May 10, 2006
The Hedgehog signaling pathway has emerged as a key regulator ...
Staying Balanced Among the Chattering Class - April 26, 2006
Neurons are constantly engaged in a chatter of synaptic transmission ...
Correlated Neural Activity Dictates Changes in Visual Information Processing - April 5, 2006
Although it is generally agreed that neural activity plays an ...
Running Through Stop Signs - March 28, 2006
One of the 10 biological commandments is "Thou shall keep ...
Validation of Polo-like Kinase 1 as a Cancer Therapy Target - March 6, 2006
A new study from the Erikson lab by Xiaoqi Liu ...
A New Function and Mechanism for MicroRNAs - Feb. 21, 2006
Research by Antonio Giraldez, Alex Schier, and their collaborators now ...
An Unusually Simple Signal Transduction System - Feb. 10, 2006
In this week’s Cell, Craig Ellermeier, Errett Hobbs, Eduardo ...
MCB News Tags:  2006, Cell, publication, Richard Losick
A New Mechanism for Long-term Memory - Jan. 13, 2006
We have provided a first glimpse of protein synthesis at ...
MCB News Tags:  2006, Cell, publication, Sam Kunes
Neural Tube Defects: Insights from Zebrafish - Jan. 13, 2006
In this week’s Nature, Brian Ciruna, Alex Schier and ...
A New Way to Study Spinal Cord Injury - Dec. 7, 2005
A tragic truth is that the mammalian central nervous system ...
Sex and Smell: the Molecular Architecture of Pheromone Sensing - Nov. 18, 2005
In a set of experiments published in the November 17 ...
MCB News Tags:  2005, Catherine Dulac, Cell, publication
Who Calls the Shots When the Synapse Forms? - Oct. 6, 2005
The synapse is the heart of the nervous system, the ...
Caspases and Nitric Oxide Regulate Dendritic Cell Maturation - Oct. 3, 2005
A paper from the Strominger lab sheds interesting new light ...
How to Make a Membrane - Sept. 13, 2005
The ingredients of a human cell include about 100,000 ...
Human Embryonic Stem Cells Can Reprogram Adult Somatic Nuclei - Aug. 26, 2005
To test whether Human Embryonic Stem (hES) cells could reprogram ...
Unraveling our Plumbing - Aug. 2, 2005
Water and salt balance in our bodies and removal of ...
The Retina Seeks Novelty - July 7, 2005
Our eyes report the visual world to the brain, but ...
E. Coli Swim on the Right-Hand Side - June 30, 2005
Researchers working together in the Howard Berg lab in MCB ...
MCB News Tags:  2005, Howard Berg, Nature, publication
Chromosome and Replisome Dynamics in E. coli - June 17, 2005
All cells are faced with two very basic problems each ...
MCB News Tags:  2005, Cell, Nancy Kleckner, publication
CCT is Required for the Biogenesis of Functional Plk1 - May 31, 2005
The polo-like kinase (plk) family has emerged as a key ...
Developmental Commitment in B. Subtilis - May 6, 2005
Studying Bacillus subtilis, a microbe that can form spores when ...
MCB News Tags:  2005, Cell, publication, Richard Losick
Vesicle Recycling After Endocytosis - April 27, 2005
Communication between neurons occurs at specialized structures called synapses, where ...
Structure of a Bacterial Centromere - March 25, 2005
Dividing cells face the challenge of ensuring that newly duplicated ...
Mammalian SAD Kinases Are Required for Neuronal Polarization - Feb. 11, 2005
A recent study by Kishi et al. shows how research ...
MCB News Tags:  2005, Joshua Sanes, publication, Science
Bioinformatic Dissection of High-Level Cellular Behavior - Jan. 19, 2005
Although microarray technology is wildly popular among biologists, even its ...
Faithful Chromosome Segregation - Jan. 19, 2005
Errors in chromosome segregation lead to disease and death. To ...
Axon Branch Removal at Developing Synapses by Axosome Shedding - Nov. 18, 2004
This work (Neuron 2004, 44:651-661) decides a question that ...
MCB News Tags:  2004, Jeff Lichtman, Neuron, publication
Genomic Analysis of Sporulation in Bacillus Subtilis - Sept. 21, 2004
A fundamental challenge in the field of development is to ...
Do Chromosomes Work through Stress? - Aug. 25, 2004
A paper in the August 24 issue of Proceedings of ...
Mathematical Models of Robustness in Development - Aug. 12, 2004
A paper by Nicholas Ingolia in the June 15, 2004 ...
Finding a Presynaptic Organizer That Makes the Brain Functional - July 22, 2004
Neurons analyze and transmit information in the brain. Information is ...
MCB News Tags:  2004, Cell, Joshua Sanes, publication
New Light on Crossover Differentiation - June 16, 2004
A paper just published from the Kleckner lab in Cell ...
MCB News Tags:  2004, Cell, Nancy Kleckner, publication
Development Study Finds Potential Signaling Code for Certain Facial Features - May 27, 2004
Researchers in the lab of MCB department chair Andrew McMahon ...
The In Vivo Contribution of Adult Stem Cells to Organ Maintenance and Repair - May 7, 2004
A paper from the Melton group (Dor, Brown, Martinez, and ...