Harvard University - Department of Molecular & Cellular Biology

MEMBERS OF THE BOARD OF TUTORS

Clapham, David, M.D., Ph.D.

Department of Neurobiology, Children's Hospital

http://clapham.tch.harvard.edu/

profile_image Our laboratory is interested in the signal transduction control of ion channel activity and the role of calcium as an intracellular messenger. The human genome contains several hundred genes that encode ion channels brokering the passage of charged ions across impermeable lipid bilayers. While energy-requiring pumps labor to build charge and concentration gradients across the membrane, ion channels spend this stored energy, much as a switch releases the electrical energy of a battery. Small conformational changes cause channels to open, allowing ~10 million ions to flow per second. Normal concentrations of free intracellular Ca2+ are 20,000-fold lower than extracellular concentrations, and cells tightly regulate these intracellular levels. Excitable cells have been equipped with specialized voltage-sensitive and highly selective Ca2+ channels. Opening of these channels provides the sharp, decisive rise in Ca2+ required for rapid contraction in heart and skeletal muscle, as well as for exocytosis at nerve terminals. Nonexcitable cells, such as blood cells and cells of solid organs, use a distinct set of Ca2+-permeant channels. My laboratory is investigating the various ways Ca2+ entry into cells is controlled by newly discovered classes of ion channels.

next tutor: Clardy, John

Below is a listing of current tutors:

  • (1)   Aldovini, Anna , M.D., Division of Infectious Diseases, Children's Hospital
  • (2)   Auld, David , Ph.D., Department of Biology, Boston College
  • (3)   Ausubel, Frederick , Ph.D., Department of Molecular Biology, Massachusetts General Hospital
  • (4)   Berg, Howard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (5)   Brenner, Michael , Ph.D., Division of Engineering and Applied Sciences, Harvard University
  • (6)   Brenner, Tamara , Ph.D., Life Sciences Division, Harvard University
  • (7)   Buratowski, Stephen , Ph.D., BCMP, Harvard Medical School
  • (8)   Burton, Briana , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (9)   Carroll, Michael , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (10)   Chen, Bing , Ph.D., Laboratory of Molecular Medicine, Children's Hospital
  • (11)   Chou, James , Ph.D., BCMP, Harvard Medical School
  • (12)   Clapham, David , M.D., Ph.D., Department of Neurobiology, Children's Hospital
  • (13)   Clardy, John , Ph.D., BCMP, Harvard Medical School
  • (14)   D'Souza, Victoria , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (15)   DePace, Angela , Ph.D., Department of Systems Biology, Harvard Medical School
  • (16)   Dulac, Catherine , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (17)   Eck, Michael , M.D., Ph.D., BCMP, Dana-Farber Cancer Institute
  • (18)   Eggan, Kevin , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (19)   Engert, Florian , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (20)   Erikson, Raymond , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (21)   Fisher, David , M.D., Ph.D., Department of Pediatrics, Dana Farber Cancer Institute
  • (22)   Fraenkel, Dan , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (23)   Fraenkel, Ernest , Ph.D., Division of Biological Engineering, Massachusetts Institute of Technology
  • (24)   Fraenkel, Paula , M.D., Hematology/Oncology, Beth Israel Deaconess Medical Center
  • (25)   Gaudet, Rachelle , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (26)   Goldfeld, Anne , M.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (27)   Goldstein, Richard , Ph.D., Professor of Pediatrics, Boston Medical Center
  • (28)   Gray, Nathanael , Ph.D., BCMP, Harvard Medical School
  • (29)   Guidotti, Guido , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (30)   Haigis, Marcia , Ph.D., Department of Pathology, Harvard Medical School
  • (31)   Harrison, Stephen , Ph.D., BCMP, Harvard Medical School
  • (32)   Hedley, Mary Lynne , Ph.D., MGI Pharma Biologics
  • (33)   Hinds, Philip , Ph.D., Molecular Oncology Research Institute, Tufts - New England Medical Center
  • (34)   Hung, Deborah , M.D., Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (35)   Hunter, Craig , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (36)   Jasanoff, Alan , Ph.D., Nuclear Engineering/Brain & Cognitive Sciences, Massachusetts Institute of Technology
  • (37)   Kahne, Daniel , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (38)   Kay, Jeremy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (39)   Kieff, Elliott , M.D., Ph.D., Channing Laboratory, Brigham and Women's Hospital
  • (40)   Kirchhausen, Tomas , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (41)   Kishony, Roy , Ph.D., Department of Systems Biology, Harvard Medical School
  • (42)   Kleckner, Nancy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (43)   Kolter, Roberto , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (44)   Kopcow, Hernan , Ph.D., Department of Medicine, Beth Israel Deaconess Medical Center
  • (45)   Kunes, Samuel , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (46)   Lahav, Galit , Ph.D., Department of Systems Biology, Harvard Medical School
  • (47)   Leschziner, Andres , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (48)   Liberles, Stephen , Ph.D., Department of Cell Biology, Harvard Medical School
  • (49)   Lichtman, Jeff , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (50)   Lieberman, Judy , M.D., Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (51)   Lilley, Brendan , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (52)   Livingston, David , M.D., Department of Genetics, Dana-Farber Cancer Institute
  • (53)   Loeken, Mary , Ph.D., Developmental and Stem Cell Biology, Joslin Diabetes Center, Harvard Medical School
  • (54)   Losick, Richard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (55)   Lue, Robert , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (56)   Magasanik, Boris , Ph.D., Biology Department, Massachusetts Institute of Technology
  • (57)   McKeon, Frank , Ph.D., Department of Cell Biology, Harvard Medical School
  • (58)   Michel, Thomas , M.D., Ph.D., Cardiovascular Division, Brigham and Women's Hospital
  • (59)   Miller, Jeffrey , Ph.D., Neuromuscular Biology & Disease Group, Boston Biomedical Research Institute
  • (60)   Miller, Theodore , Ph.D., Chief Executive Officer, Reify Corporation
  • (61)   Moazed, Danesh , Ph.D., Department of Cell Biology, Harvard Medical School
  • (62)   Murthy, Venkatesh , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (63)   Navia, Manuel , , Oxford Bioscience Partners
  • (64)   Nelson, David , Ph.D., Department of Physics, Harvard University
  • (65)   Olesen, James , Ph.D., Wilmer Cutler Pickering Hale and Door LLP
  • (66)   Peattie, Debra , MBA, Ph.D., Harvard University
  • (67)   Ranjbar, Shahin , Ph.D., Children's Hospital, Harvard Medical School
  • (68)   Rheinwald, James , Ph.D., Department of Dermatology, Brigham and Women's Hospital
  • (69)   Rivera-Feliciano, Jose , Ph.D., Stem Cell and Regenerative Biology, Harvard University
  • (70)   Sabeti, Pardis , D.Phil, M.D., FAS Center for Systems Biology, Harvard University
  • (71)   Sanes, Joshua , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (72)   Sassanfar, Mandana , Ph.D., Department of Biology, Massachusetts Institute of Technology
  • (73)   Sato, Vicki , Ph.D., Technology and Operations Management, Harvard Business School
  • (74)   Schier, Alexander , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (75)   Shamu, Caroline , Ph.D., Department of Systems Biology, Harvard Medical School
  • (76)   Shi, Yang , Ph.D., Department of Pathology, Harvard Medical School
  • (77)   Silberstein, Lev , M.D., Ph.D., Harvard University
  • (78)   Starnbach, Michael , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (79)   Stern, Bodo , Ph.D., FAS Center for Systems Biology, Harvard University
  • (80)   Stern, Joel N.H. , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (81)   Strominger, Jack , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (82)   Sweadner, Kathleen , M.D., Harvard University
  • (83)   Tong, Jeffrey , Ph.D., Nora Therapeutics
  • (84)   Torello, A. Thomas , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (85)   Toth, Joseph , Ph.D., Merrimack Pharmaceuticals
  • (86)   Tucci, Greg , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (87)   Vaughan, Cheryl , Ph.D., Graduate Program in Biotechnology, Harvard University
  • (88)   Viel, Alain , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (89)   Walker, Suzanne , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (90)   Winston, Fred , Ph.D., Department of Genetics, Harvard Medical School