Harvard University - Department of Molecular & Cellular Biology

MEMBERS OF THE BOARD OF TUTORS

Losick, Richard, Ph.D.

Department of Molecular and Cellular Biology, Harvard University

profile_image Our laboratory studies development in simple organisms that are accessible to genetic manipulation. The organisms we study are the unicellular bacterium Bacillus subtilis and the filamentous bacterium Streptomyces coelicolor. These bacterial undergo elaborate cycles of cellular differentiation that culminate in the formation of a dormant cell, the spore. In B. subtilis this differentiation cycle involves the transformation of a vegetative cell into a two-cell compartment sporangium within which the spore is produced. The two compartments receive identical chromosomes yet have dissimilar developmental fates involving differential expression of distinct sets of genes. In contrast, S. coelicolor exhibits a myelial fungus-like cycle of morphological differentiation involving the formation of upwardly projecting (aerial) hyphae that undergo septation into long chains of uninucleate cells, which, in turn metamorphose into pigmented spores. In B. subtilis we are focusing on the questions of how a progenitor cell (the vegetative bacterium give rise to dissimilar progeny (the cellular compartments of the sporangium) and how the two sporangial compartments communicate with each other so as to coordinate developmental gene expression with the course of morphogenesis. In S. coelicolor we are investigating how aerial hyphae are erected and metamorphose into spores, and how morphological differentiation is governed by the exchange of chemical signals between cells.

next tutor: Lue, Robert

Below is a listing of current tutors:

  • (1)   Aldovini, Anna , M.D., Division of Infectious Diseases, Children's Hospital
  • (2)   Auld, David , Ph.D., Department of Biology, Boston College
  • (3)   Ausubel, Frederick , Ph.D., Department of Molecular Biology, Massachusetts General Hospital
  • (4)   Berg, Howard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (5)   Brenner, Michael , Ph.D., Division of Engineering and Applied Sciences, Harvard University
  • (6)   Brenner, Tamara , Ph.D., Life Sciences Division, Harvard University
  • (7)   Buratowski, Stephen , Ph.D., BCMP, Harvard Medical School
  • (8)   Burton, Briana , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (9)   Carroll, Michael , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (10)   Chen, Bing , Ph.D., Laboratory of Molecular Medicine, Children's Hospital
  • (11)   Chou, James , Ph.D., BCMP, Harvard Medical School
  • (12)   Clapham, David , M.D., Ph.D., Department of Neurobiology, Children's Hospital
  • (13)   Clardy, John , Ph.D., BCMP, Harvard Medical School
  • (14)   D'Souza, Victoria , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (15)   DePace, Angela , Ph.D., Department of Systems Biology, Harvard Medical School
  • (16)   Dulac, Catherine , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (17)   Eck, Michael , M.D., Ph.D., BCMP, Dana-Farber Cancer Institute
  • (18)   Eggan, Kevin , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (19)   Engert, Florian , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (20)   Erikson, Raymond , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (21)   Fisher, David , M.D., Ph.D., Department of Pediatrics, Dana Farber Cancer Institute
  • (22)   Fraenkel, Dan , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (23)   Fraenkel, Ernest , Ph.D., Division of Biological Engineering, Massachusetts Institute of Technology
  • (24)   Fraenkel, Paula , M.D., Hematology/Oncology, Beth Israel Deaconess Medical Center
  • (25)   Gaudet, Rachelle , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (26)   Goldfeld, Anne , M.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (27)   Goldstein, Richard , Ph.D., Professor of Pediatrics, Boston Medical Center
  • (28)   Gray, Nathanael , Ph.D., BCMP, Harvard Medical School
  • (29)   Guidotti, Guido , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (30)   Haigis, Marcia , Ph.D., Department of Pathology, Harvard Medical School
  • (31)   Harrison, Stephen , Ph.D., BCMP, Harvard Medical School
  • (32)   Hedley, Mary Lynne , Ph.D., MGI Pharma Biologics
  • (33)   Hinds, Philip , Ph.D., Molecular Oncology Research Institute, Tufts - New England Medical Center
  • (34)   Hung, Deborah , M.D., Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (35)   Hunter, Craig , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (36)   Jasanoff, Alan , Ph.D., Nuclear Engineering/Brain & Cognitive Sciences, Massachusetts Institute of Technology
  • (37)   Kahne, Daniel , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (38)   Kay, Jeremy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (39)   Kieff, Elliott , M.D., Ph.D., Channing Laboratory, Brigham and Women's Hospital
  • (40)   Kirchhausen, Tomas , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (41)   Kishony, Roy , Ph.D., Department of Systems Biology, Harvard Medical School
  • (42)   Kleckner, Nancy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (43)   Kolter, Roberto , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (44)   Kopcow, Hernan , Ph.D., Department of Medicine, Beth Israel Deaconess Medical Center
  • (45)   Kunes, Samuel , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (46)   Lahav, Galit , Ph.D., Department of Systems Biology, Harvard Medical School
  • (47)   Leschziner, Andres , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (48)   Liberles, Stephen , Ph.D., Department of Cell Biology, Harvard Medical School
  • (49)   Lichtman, Jeff , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (50)   Lieberman, Judy , M.D., Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (51)   Lilley, Brendan , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (52)   Livingston, David , M.D., Department of Genetics, Dana-Farber Cancer Institute
  • (53)   Loeken, Mary , Ph.D., Developmental and Stem Cell Biology, Joslin Diabetes Center, Harvard Medical School
  • (54)   Losick, Richard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (55)   Lue, Robert , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (56)   Magasanik, Boris , Ph.D., Biology Department, Massachusetts Institute of Technology
  • (57)   McKeon, Frank , Ph.D., Department of Cell Biology, Harvard Medical School
  • (58)   Michel, Thomas , M.D., Ph.D., Cardiovascular Division, Brigham and Women's Hospital
  • (59)   Miller, Jeffrey , Ph.D., Neuromuscular Biology & Disease Group, Boston Biomedical Research Institute
  • (60)   Miller, Theodore , Ph.D., Chief Executive Officer, Reify Corporation
  • (61)   Moazed, Danesh , Ph.D., Department of Cell Biology, Harvard Medical School
  • (62)   Murthy, Venkatesh , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (63)   Navia, Manuel , , Oxford Bioscience Partners
  • (64)   Nelson, David , Ph.D., Department of Physics, Harvard University
  • (65)   Olesen, James , Ph.D., Wilmer Cutler Pickering Hale and Door LLP
  • (66)   Peattie, Debra , MBA, Ph.D., Harvard University
  • (67)   Ranjbar, Shahin , Ph.D., Children's Hospital, Harvard Medical School
  • (68)   Rheinwald, James , Ph.D., Department of Dermatology, Brigham and Women's Hospital
  • (69)   Rivera-Feliciano, Jose , Ph.D., Stem Cell and Regenerative Biology, Harvard University
  • (70)   Sabeti, Pardis , D.Phil, M.D., FAS Center for Systems Biology, Harvard University
  • (71)   Sanes, Joshua , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (72)   Sassanfar, Mandana , Ph.D., Department of Biology, Massachusetts Institute of Technology
  • (73)   Sato, Vicki , Ph.D., Technology and Operations Management, Harvard Business School
  • (74)   Schier, Alexander , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (75)   Shamu, Caroline , Ph.D., Department of Systems Biology, Harvard Medical School
  • (76)   Shi, Yang , Ph.D., Department of Pathology, Harvard Medical School
  • (77)   Silberstein, Lev , M.D., Ph.D., Harvard University
  • (78)   Starnbach, Michael , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (79)   Stern, Bodo , Ph.D., FAS Center for Systems Biology, Harvard University
  • (80)   Stern, Joel N.H. , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (81)   Strominger, Jack , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (82)   Sweadner, Kathleen , M.D., Harvard University
  • (83)   Tong, Jeffrey , Ph.D., Nora Therapeutics
  • (84)   Torello, A. Thomas , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (85)   Toth, Joseph , Ph.D., Merrimack Pharmaceuticals
  • (86)   Tucci, Greg , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (87)   Vaughan, Cheryl , Ph.D., Graduate Program in Biotechnology, Harvard University
  • (88)   Viel, Alain , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (89)   Walker, Suzanne , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (90)   Winston, Fred , Ph.D., Department of Genetics, Harvard Medical School