Harvard University - Department of Molecular & Cellular Biology

MEMBERS OF THE BOARD OF TUTORS

DePace, Angela, Ph.D.

Department of Systems Biology, Harvard Medical School

http://depace.med.harvard.edu/

profile_image My group is broadly interested in the evolution of transcriptional networks in animals. Whole genome sequence for a wide variety of organisms has shown us that across taxa, the set of protein coding genes is remarkably similar. How is this common genetic toolkit deployed in new configurations to generate organismal diversity? The evolutionary importance of changes in gene regulation during development is now clear, and a handful of examples have successfully traced the path from distinct phenotypes, to changes in gene expression, and finally to specific changes in genomic regulatory sequence. Yet we lack general principles describing how regulatory sequence relates to its output as gene expression patterns in space and time, severely limiting our understanding of how these sequences are functionally constrained during evolution.

Gene expression in metazoans is controlled by the interaction among cis-regulatory elements (sometimes called enhancers), silencers, insulators, chromatin structure and core promoters. The vast majority of gene specific spatial and temporal information is contained in cis-regulatory elements, which are collections of binding sites for sequence specific DNA-binding transcription factors. Our current work is focused on two parallel questions. First, how do collections of transcription factor binding sites integrate information to produce gene expression patterns? And second, how do cis-regulatory elements and their associated expression patterns evolve?

We focus on the early development of multiple Drosophila species, and integrate a wide variety of experimental and computational approaches. The early development of Drosophila melanogaster is directed by an extremely well characterized transcriptional network, giving us a large number of known transcription factors and regulatory elements to work with. Twelve Drosophila species have recently been sequenced, and more genomic resources are on the way. The relatively simple geometry of the early embryo has allowed us to develop quantitative imaging techniques that yield gene expression information for every cell in the entire embryo over time. Together, these resources give us the opportunity to bring a quantitative system-wide approach to evolutionary developmental biology.

next tutor: Dulac, Catherine

Below is a listing of current tutors:

  • (1)   Aldovini, Anna , M.D., Division of Infectious Diseases, Children's Hospital
  • (2)   Auld, David , Ph.D., Department of Biology, Boston College
  • (3)   Ausubel, Frederick , Ph.D., Department of Molecular Biology, Massachusetts General Hospital
  • (4)   Berg, Howard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (5)   Brenner, Michael , Ph.D., Division of Engineering and Applied Sciences, Harvard University
  • (6)   Brenner, Tamara , Ph.D., Life Sciences Division, Harvard University
  • (7)   Buratowski, Stephen , Ph.D., BCMP, Harvard Medical School
  • (8)   Burton, Briana , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (9)   Carroll, Michael , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (10)   Chen, Bing , Ph.D., Laboratory of Molecular Medicine, Children's Hospital
  • (11)   Chou, James , Ph.D., BCMP, Harvard Medical School
  • (12)   Clapham, David , M.D., Ph.D., Department of Neurobiology, Children's Hospital
  • (13)   Clardy, John , Ph.D., BCMP, Harvard Medical School
  • (14)   D'Souza, Victoria , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (15)   DePace, Angela , Ph.D., Department of Systems Biology, Harvard Medical School
  • (16)   Dulac, Catherine , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (17)   Eck, Michael , M.D., Ph.D., BCMP, Dana-Farber Cancer Institute
  • (18)   Eggan, Kevin , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (19)   Engert, Florian , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (20)   Erikson, Raymond , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (21)   Fisher, David , M.D., Ph.D., Department of Pediatrics, Dana Farber Cancer Institute
  • (22)   Fraenkel, Dan , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (23)   Fraenkel, Ernest , Ph.D., Division of Biological Engineering, Massachusetts Institute of Technology
  • (24)   Fraenkel, Paula , M.D., Hematology/Oncology, Beth Israel Deaconess Medical Center
  • (25)   Gaudet, Rachelle , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (26)   Goldfeld, Anne , M.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (27)   Goldstein, Richard , Ph.D., Professor of Pediatrics, Boston Medical Center
  • (28)   Gray, Nathanael , Ph.D., BCMP, Harvard Medical School
  • (29)   Guidotti, Guido , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (30)   Haigis, Marcia , Ph.D., Department of Pathology, Harvard Medical School
  • (31)   Harrison, Stephen , Ph.D., BCMP, Harvard Medical School
  • (32)   Hedley, Mary Lynne , Ph.D., MGI Pharma Biologics
  • (33)   Hinds, Philip , Ph.D., Molecular Oncology Research Institute, Tufts - New England Medical Center
  • (34)   Hung, Deborah , M.D., Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (35)   Hunter, Craig , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (36)   Jasanoff, Alan , Ph.D., Nuclear Engineering/Brain & Cognitive Sciences, Massachusetts Institute of Technology
  • (37)   Kahne, Daniel , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (38)   Kay, Jeremy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (39)   Kieff, Elliott , M.D., Ph.D., Channing Laboratory, Brigham and Women's Hospital
  • (40)   Kirchhausen, Tomas , Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (41)   Kishony, Roy , Ph.D., Department of Systems Biology, Harvard Medical School
  • (42)   Kleckner, Nancy , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (43)   Kolter, Roberto , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (44)   Kopcow, Hernan , Ph.D., Department of Medicine, Beth Israel Deaconess Medical Center
  • (45)   Kunes, Samuel , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (46)   Lahav, Galit , Ph.D., Department of Systems Biology, Harvard Medical School
  • (47)   Leschziner, Andres , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (48)   Liberles, Stephen , Ph.D., Department of Cell Biology, Harvard Medical School
  • (49)   Lichtman, Jeff , M.D., Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (50)   Lieberman, Judy , M.D., Ph.D., CBR Institute for Biomedical Research, Harvard Medical School
  • (51)   Lilley, Brendan , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (52)   Livingston, David , M.D., Department of Genetics, Dana-Farber Cancer Institute
  • (53)   Loeken, Mary , Ph.D., Developmental and Stem Cell Biology, Joslin Diabetes Center, Harvard Medical School
  • (54)   Losick, Richard , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (55)   Lue, Robert , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (56)   Magasanik, Boris , Ph.D., Biology Department, Massachusetts Institute of Technology
  • (57)   McKeon, Frank , Ph.D., Department of Cell Biology, Harvard Medical School
  • (58)   Michel, Thomas , M.D., Ph.D., Cardiovascular Division, Brigham and Women's Hospital
  • (59)   Miller, Jeffrey , Ph.D., Neuromuscular Biology & Disease Group, Boston Biomedical Research Institute
  • (60)   Miller, Theodore , Ph.D., Chief Executive Officer, Reify Corporation
  • (61)   Moazed, Danesh , Ph.D., Department of Cell Biology, Harvard Medical School
  • (62)   Murthy, Venkatesh , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (63)   Navia, Manuel , , Oxford Bioscience Partners
  • (64)   Nelson, David , Ph.D., Department of Physics, Harvard University
  • (65)   Olesen, James , Ph.D., Wilmer Cutler Pickering Hale and Door LLP
  • (66)   Peattie, Debra , MBA, Ph.D., Harvard University
  • (67)   Ranjbar, Shahin , Ph.D., Children's Hospital, Harvard Medical School
  • (68)   Rheinwald, James , Ph.D., Department of Dermatology, Brigham and Women's Hospital
  • (69)   Rivera-Feliciano, Jose , Ph.D., Stem Cell and Regenerative Biology, Harvard University
  • (70)   Sabeti, Pardis , D.Phil, M.D., FAS Center for Systems Biology, Harvard University
  • (71)   Sanes, Joshua , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (72)   Sassanfar, Mandana , Ph.D., Department of Biology, Massachusetts Institute of Technology
  • (73)   Sato, Vicki , Ph.D., Technology and Operations Management, Harvard Business School
  • (74)   Schier, Alexander , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (75)   Shamu, Caroline , Ph.D., Department of Systems Biology, Harvard Medical School
  • (76)   Shi, Yang , Ph.D., Department of Pathology, Harvard Medical School
  • (77)   Silberstein, Lev , M.D., Ph.D., Harvard University
  • (78)   Starnbach, Michael , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (79)   Stern, Bodo , Ph.D., FAS Center for Systems Biology, Harvard University
  • (80)   Stern, Joel N.H. , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (81)   Strominger, Jack , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (82)   Sweadner, Kathleen , M.D., Harvard University
  • (83)   Tong, Jeffrey , Ph.D., Nora Therapeutics
  • (84)   Torello, A. Thomas , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (85)   Toth, Joseph , Ph.D., Merrimack Pharmaceuticals
  • (86)   Tucci, Greg , Ph.D., Department of Chemistry and Chemical Biology, Harvard University
  • (87)   Vaughan, Cheryl , Ph.D., Graduate Program in Biotechnology, Harvard University
  • (88)   Viel, Alain , Ph.D., Department of Molecular and Cellular Biology, Harvard University
  • (89)   Walker, Suzanne , Ph.D., Microbiology and Molecular Genetics, Harvard Medical School
  • (90)   Winston, Fred , Ph.D., Department of Genetics, Harvard Medical School