News from 2015

  • Archive

RECONSTRUCTING THE BRAINS WIRING DIAGRAM [LICHTMAN LAB]

(l to r) Jeff Lichtman, Josh Morgan, Jose Conchello, Daniel Berger, and Richard Schalek This paper describes a suite of automated technologies designed to probe the structure of…

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CLEARED TISSUE IMAGING AT THE HARVARD CENTER FOR BIOLOGICAL IMAGING

Jeff Lichtman (l) and Doug Richardson The Harvard Center for Biological Imaging (HCBI) recently celebrated its five year anniversary. A central pillar in its mandate is to ensure…

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CHROMOSOMES AS MECHANICAL OBJECTS [KLECKNER LAB]

Zhangyi Liang We have suggested that chromosomes should be viewed as macroscopic mechanical objects whose functions are governed by accumulation, release and redistribution of mechanical stress.  We have…

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BUILDING A CLUB SANDWICH [SANES LAB]

(l to r) Xin Duan, Arjun Krishnaswamy, and Josh Sanes The aim of developmental neurobiology is to learn how the nervous system is built, and to find the…

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A MASTER REGULATOR FOR CIRCADIAN GENE EXPRESSION [O’SHEA LAB]

(l to r) Anna Puszynska, Joseph Piechura, and Erin O'Shea (not shown Joseph Markson) Organisms from humans to bacteria utilize endogenous timing mechanisms called circadian clocks to coordinate…

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SWR1 [LESCHZINER LAB]

(l to r) Carl Wu, Vu Nguyen, Debbie Wei, Anand Ranjan, and Andres Leschziner Genome packaging is a universal process in eukaryotes.  In the smallest repeating unit of…

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HOW DOES E. COLI SEGREGATE ITS SISTERS WITHOUT A SPINDLE? [KLECKNER LAB]

(l to r) Guillaume Witz, Mara Prentiss, Nancy Kleckner, Beth Weiner, and Jay K. Fisher The E. coli chromosome is a single circular unit which, if stretched out,…

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DYNEIN PUTS ITS BEST FOOT FORWARD [LESCHZINER LAB]

(L to R) Sirui Zou, Bret Redwine, Andres Leschziner, Rogelio Hernandez-Lopez, and Samara Reck-Peterson, front row Locksley Walking takes an enormous amount of coordination. As your leading foot…

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HOW DO PLURIPOTENT CELLS CHOOSE A FATE?

A fundamental question in developmental biology is how multi-potent cells choose a fate. While we know a lot about how cell states are maintained through growing amounts of…

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HOW TO FIND YOUR HOMOLOG WITHOUT LOSING YOUR SISTER

Meiosis is a modified cellular program by which a single diploid cell gives rise to haploid gametes (e.g. sperm and egg). To this end, DNA replication is followed…

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