News from 2017

  • Research

A Little of Magic Spot Goes a Long Way in Cyanobacteria [O’Shea Lab]

Guanosine tetraphosphate and pentaphosphate,  collectively known as (p)ppGpp or magic spot nucleotides, are effectors of the stringent response, a stress response pathway activated during nutrient and energy deprivation.…

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  • Research

How Do Environmental Stimuli Set Individual Circadian Clocks to Stochastic Phases? [O’Shea Lab]

Many organisms on earth have evolved an endogenous self-sustained pacemaker, called the circadian clock, to anticipate daily changes in the environment and adapt its physiology. The circadian clock…

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  • Research

Do Not Go Rhythmless into That Good Night [O’Shea Lab]

The cycle of day and night is one of the most recurrent and predictable environmental change on our planet. Consequently, organisms evolved mechanisms that give them an ability…

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  • Education

MCB POSTDOC WINS SECOND FELLOWSHIP TO STUDY AUTOPHAGY

Postdoctoral student Chris Shoemaker of the Denic Lab, who previously won a fellowship from the Damon Runyon Cancer Research Foundation, has now won the Pathway to Independence (K99)…

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  • Research

A NATURAL ANTICANCER COMPOUND DESTABILIZES THE CELL MEMBRANE BY REACTING WITH LIPIDS [O’SHEA LAB]

Many of the approved chemotherapy drugs are either collected from natural sources or inspired by molecules existing in nature. Natural products with anticancer activity can be readily identified…

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  • Archive

RADIO BROADCASTING IN CELLS [O’SHEA LAB]

Anders Sejr Hansen To survive, cells must monitor their environments and elicit appropriate and timely responses to external stresses such as nutrient deprivation. In general, cells achieve this…

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  • Archive

COUPLING TRANSCRIPTION AND TRANSLATION IN EUKARYOTES [O’SHEA LAB]

Erin O'Shea (l) and Brian Zid The central dogma of molecular biology proposes that information flows from DNA to RNA through the process of transcription and from RNA…

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  • Archive

STOCHASTIC ORGANELLE BIOGENESIS [O’SHEA LAB]

Erin O’Shea and Shankar Mukherji Cells are kind of like little people. Just like we have organs like our heart, lungs and brain that are responsible for core…

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  • Archive

A MASTER REGULATOR FOR CIRCADIAN GENE EXPRESSION [O’SHEA LAB]

(l to r) Anna Puszynska, Joseph Piechura, and Erin O'Shea (not shown Joseph Markson) Organisms from humans to bacteria utilize endogenous timing mechanisms called circadian clocks to coordinate…

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