News from 2015

  • Archive

DESTRUCTION ON DEMAND [DENIC LAB]

(l to r) Vlad Denic, Roarke Kamber, and Chris Shoemaker The modern urbanite doesn’t bother with the bus – she taps her phone and meets a personal driver…

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MOLECULAR CLOCKWORK OF BACTERIAL TIME-KEEPING [O’SHEA LAB]

Erin O'Shea (l) and Andrian Gutu The day-night cycle is the most predictable environmental variation on Earth. Many organisms, ranging from bacteria to humans have evolved endogenous time-keeping…

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RNAI ON THE MENU [HUNTER LAB]

(L to R) Craig Hunter, Deborah McEwan, and Alexandra Weisman What if your lunch could tell your body to shut off a particular gene?  This is exactly what…

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HOW TO SHUCK A SPECIALIZED CHAPERONE

(L-R) Vlad Denic, Fei Wang, Matthew Tung Eukaryotic cells target a large fraction of proteins synthesized in the cytosol to a number of different intracellular membrane compartments (organelles).…

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CISCODE, TRANS EFFECT, TRANSCRIPTION SPECIFICITY

Erin K. O'Shea and Xu Zhou Gene expression is controlled by a class of proteins called transcription factors. These proteins usually bind to short 6-8 base pair DNA…

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THE MOVING PARTS OF A TAIL-ANCHORED PROTEIN SORTING MACHINE

(L to R) Vladimir Denic and Fei Wang Membrane protein targeting is a fundamental problem in cell biology. Pioneering work by George Palade in the 1960s established that…

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HOW NOT TO WEAR OUT A WELCOME

Seung-Hwan Kim and Matthew Michael Just as dinner party guests who linger at the table long after coffee and dessert can strain the patience of their hosts, an…

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SWITCHING ON BRAIN-SPECIFIC ALTERNATIVE SPLICING WITH A MICRORNA

Jiangwen Zhang, Monica Carrasco, Eugene Makeyev and Tom Maniatis Cellular differentiation requires global changes in gene expression at both transcriptional and posttranscriptional levels. Posttranscriptional regulation provides a mechanism…

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PUTTING A FACE ON A CLASS OF VIRAL DEUBIQUITINATING ENZYMES

(l to r) Authors Wilhelm Weihofen, Rachelle Gaudet and Christian Schlieker Herpesviruses (members of the Herpesviridae family) are widespread pathogens, causing disease in humans and animals. The family…

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TAP’S TWO-CYLINDER ENGINE

Authors Ian Errin-O'Connell, Eik Procko, Sze-Ling Ng and Rachelle Gaudet In nearly all human cells, TAP, the ABC Transporter associated with Antigen Processing, transports small antigen peptides across…

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