News from 2018

  • Research

The Intricacies of Embryonic Signaling [Schier Lab]

In three papers in eLife, the Schier lab provides surprising insights into the regulation of early vertebrate embryogenesis.  Focusing on the roles of the TGF-b Nodal signaling pathway,…

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  • Research

Unmasking the Function of Oxytocin in Neuronal and Behavioral Sex Discrimination [Dulac Lab]

Oxytocin and its cognate receptor have been proposed as essential mediators of social behaviors, physiological functions, and emotional responses in many animal species. Oxytocin is an evolutionarily conserved…

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  • Research

A Little of Magic Spot Goes a Long Way in Cyanobacteria [O’Shea Lab]

Guanosine tetraphosphate and pentaphosphate,  collectively known as (p)ppGpp or magic spot nucleotides, are effectors of the stringent response, a stress response pathway activated during nutrient and energy deprivation.…

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  • Research

A Code for mRNA Decay [Schier Lab]

To make a change, we must replace old with new: plow the field to seed new plants, abandon old habits to adapt new ones, and erase the board…

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  • Research

The Brightest are Not Always the Best: A Guide to Selecting Fluorescent Proteins [Cluzel Lab]

When selecting fluorescent proteins (FPs), it is standard practice to select FPs with the highest in vitro brightness. However, it is well-known that in vitro brightness does not…

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  • Research

The Brain Representation of Social Information [Dulac and Murthy Labs]

Behaviors such as mating, territorial defense, parenting or predator avoidance, despite being instinctive, are modulated by social experience. Because instinctive behaviors can be elicited without any previous social…

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  • Research

Twinkle, Twinkle Little Neuron: Watching Newborn Neurons Grow Up in the Adult Brain [Murthy Lab]

Sensory systems must be adaptive to allow animals to cope with changing environments. For hundreds of years, neuroscientists thought that neural plasticity came from changes in the connections…

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  • Research

Controlling Organellar Excess: Msp1 Eliminates Undesired Membrane Proteins from Mitochondria and Peroxisomes [Denic Lab]

The phrase “finding a needle in a haystack” refers to the difficulty of locating a specific target among a large number of very similar objects. Living cells face…

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  • Research

Channeling Anti-viral Immunity [Hunter Lab]

The discovery of RNA interference (RNAi) in 1998 was one of the most unexpected findings in the last 30 years.  The Nobel-winning observations were made in C. elegans,…

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  • Research

Mother May I?  Inheritance of Silencing Signals in C. elegans [Hunter Lab]

RNA interference (RNAi) is a nearly ubiquitous gene silencing phenomenon triggered by introduced double-stranded RNA (dsRNA). In some animals, including the nematode Caenorhabditis elegans, RNAi is systemic, which…

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