News from 2019

  • Research

The Beginning of the End for Ricin Starts at the Tail [Denic Lab]

In the late 1970’s, the KGB inducted ricin into the “cloak and dagger” hall-of-fame by turning a more or less innocuous umbrella tip into their assassin’s weapon of…

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  • Research

A Homeostatic Circuit for Hunger [Engert and Kunes Labs]

Decades ago, pioneering studies in cats and rodents identified regions within an ancient part of the brain, the hypothalamus, that are sufficient to increase or reduce appetite. Stimulating…

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  • Research

Nramp is Quite Different from the Textbook Description of a Secondary Transporter! [Gaudet Lab]

Organisms must accumulate scarce nutrients from their environments to survive. This often involves moving molecules up a concentration gradient, which is entropically unfavorable. Active transport proteins embedded in…

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  • Education, Research

For Signaling Receptors, Location Matters [Ramanathan Lab]

For embryos to develop properly, cells must communicate with one another over long ranges through diffusive chemical signals called morphogens. These signals act as instructive cues for the…

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  • Research

For Bacillus subtilis, Fate is Just a Game [Losick Lab]

Bacillus subtilis is a bacterium with many talents. Some cells devote themselves to exploration, abandoning their relatives to live as swimming ‘motile’ cells. Others instead choose a cooperative,…

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  • Research

Computing the Evolution of Specificity in Dynamic Protein Interfaces [Gaudet Lab]

As our brain develops, neurons need to connect to each other through synapses. We study a family of proteins called clustered protocadherins that help ensure that only proper…

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  • Research

Comparative Computation Across Biological and Artificial Neural Networks [Engert- and Schier Labs]

In a recent paper in Neuron (PDF) the Engert and Schier labs uncover striking similarities in stimulus representation and computation across biological and artificial neural networks performing temperature…

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  • Research

Pain in the (Fish) Brain [Engert-, Kunes-, and Schier Labs]

When we think of the neurons that control pain-induced behavior, what usually comes to mind are the simple peripheral and spinal reflex circuits described in medical textbooks. This…

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  • Research

Gut Microbes Eat our Medication

The first time Vayu Maini Rekdal manipulated microbes, he made a decent sourdough bread. At the time, young Maini Rekdal, and most people who head to the kitchen,…

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  • Research

Remodeling Flagellar Motors [Berg Lab]

Most bacteria swim through fluids by rotating helical flagella, driven at their base by a macromolecular rotary motor. The motor drives the flagellum against the viscous resistance of…

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