News from 2019

Nramp is Quite Different from the Textbook Description of a Secondary Transporter! [Gaudet Lab]

Organisms must accumulate scarce nutrients from their environments to survive. This often involves moving molecules up a concentration gradient, which is entropically unfavorable. Active transport proteins embedded in…

Read more

MCO Grad Student Elizabeth May Named as Aramont Fund Fellow!

MCO graduate student Elizabeth May (G4) of the Gaudet Lab has received a fellowship from the Aramont Fund for Emerging Science Research in support of a project called…

Read more

Computing the Evolution of Specificity in Dynamic Protein Interfaces [Gaudet Lab]

As our brain develops, neurons need to connect to each other through synapses. We study a family of proteins called clustered protocadherins that help ensure that only proper…

Read more

José Velilla of the Gaudet Lab Receives HHMI Gilliam Fellowship [Gaudet Lab]

Chemical biology grad student José Velilla [G4] of the Gaudet Lab has been named as a recipient of HHMI’s Gilliam Fellowship for Advanced Study. The Gilliam Fellowship supports…

Read more

Rachelle Gaudet Honored with Mentoring Award

The student-run organization Harvard Graduate Women in Science and Engineering (HGWISE) has named MCB faculty Rachelle Gaudet “Mentor of the Year.” The award recognizes faculty and GSAS alumni…

Read more

Open Sesame! Engineering a Transition Metal Transporter to Uncover its Substrate Pathways [Gaudet Lab]

Transport proteins embedded in the cellular membrane move chemical cargo into and out of cells, thus facilitating the acquisition of essential nutrients. Many transport proteins evolved from a…

Read more

Phosphatases and Proteases are Distant Relatives [Losick and Gaudet Labs]

Diverse cellular and developmental processes are controlled by reversible phosphorylation – the process by which phosphates are added or removed from proteins. Reversible protein phosphorylation is widely used…

Read more

Unusual Calcium Binding Allows Flexing of a Cadherin Involved in Hearing [Gaudet Lab]

Vertebrates rely on the inner ear to convert the mechanical stimuli of sound and head movements into electrical signals that can be decoded by the brain. This process,…

Read more

INSIGHTS INTO CAUSES OF ANEMIA FROM A MEMBRANE PROTEIN STRUCTURE [GAUDET LAB]

Iron is a key micronutrient that organisms use in many biological processes. Indeed, aerobic respiration requires iron to transport oxygen in our blood, to catalyze redox reactions of…

Read more

PANNING FOR PRECIOUS METALS [GAUDET LAB]

When we think of the chemical elements of life, the “big four” of carbon, oxygen, nitrogen, and hydrogen leap to mind, and rightly so, as they make up…

Read more