News from 2019

  • Research

Computing the Evolution of Specificity in Dynamic Protein Interfaces [Gaudet Lab]

As our brain develops, neurons need to connect to each other through synapses. We study a family of proteins called clustered protocadherins that help ensure that only proper…

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  • Research

José Velilla of the Gaudet Lab Receives HHMI Gilliam Fellowship [Gaudet Lab]

Chemical biology grad student José Velilla [G4] of the Gaudet Lab has been named as a recipient of HHMI’s Gilliam Fellowship for Advanced Study. The Gilliam Fellowship supports…

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  • Education

Rachelle Gaudet Honored with Mentoring Award

The student-run organization Harvard Graduate Women in Science and Engineering (HGWISE) has named MCB faculty Rachelle Gaudet “Mentor of the Year.” The award recognizes faculty and GSAS alumni…

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  • Research

Open Sesame! Engineering a Transition Metal Transporter to Uncover its Substrate Pathways [Gaudet Lab]

Transport proteins embedded in the cellular membrane move chemical cargo into and out of cells, thus facilitating the acquisition of essential nutrients. Many transport proteins evolved from a…

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  • Research

Phosphatases and Proteases are Distant Relatives [Losick and Gaudet Labs]

Diverse cellular and developmental processes are controlled by reversible phosphorylation – the process by which phosphates are added or removed from proteins. Reversible protein phosphorylation is widely used…

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  • Research

Unusual Calcium Binding Allows Flexing of a Cadherin Involved in Hearing [Gaudet Lab]

Vertebrates rely on the inner ear to convert the mechanical stimuli of sound and head movements into electrical signals that can be decoded by the brain. This process,…

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  • Research

INSIGHTS INTO CAUSES OF ANEMIA FROM A MEMBRANE PROTEIN STRUCTURE [GAUDET LAB]

Iron is a key micronutrient that organisms use in many biological processes. Indeed, aerobic respiration requires iron to transport oxygen in our blood, to catalyze redox reactions of…

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  • Research

PANNING FOR PRECIOUS METALS [GAUDET LAB]

When we think of the chemical elements of life, the “big four” of carbon, oxygen, nitrogen, and hydrogen leap to mind, and rightly so, as they make up…

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  • Research

DECIPHERING PROTEIN INTERFACES THAT HELP WIRE THE BRAIN [GAUDET LAB]

During brain development, neurons connect with each other using branched projections called dendrites. As a dendrite extends away from its neuron’s cell body to connect with dendrites from…

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  • Research

A NEURONAL BAR CODE IN 3D [GAUDET LAB]

John M. Nicoludis (l) and Rachelle Gaudet As the brain develops, neurons play a complicated game of Twister: they have to keep their neuronal processes from getting tangled…

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