Cryo-electron microscopy requires vitrifying samples in the frozen hydrated state.
However, conventional cryo-plunging is limited to samples up to ~10 µm in thickness, restricting access to many fully differentiated cell types. My research focuses on developing enhanced cryo-plunging instruments designed to improve sample cooling rates and thereby increase vitrification depth. This work may pave the way towards cryo-plunging instruments that would enable deep and rapid cryo-vitrification at atmospheric pressure and would facilitate cryo-imaging of differentiated cell types and complex multicellular systems inaccessible by current state-of-the-art methods