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Max and Anne Wien Professor of Life Sciences

Jeffrey Macklis

Max and Anne Wien Professor of Life Sciences

Professor of Stem Cell and Regenerative Biology

Research

The lab focuses on neocortical projection neuron development and sub-type specification; neural progenitor / “stem cell” biology; induction of adult neurogenesis (the birth of new neurons); subtype-specific axonal growth cone biology; and directed neuronal subtype differentiation via molecular manipulation of neural progenitors and pluripotent cells (ES/iPS). The same biology informs understanding of neuronal subtype specificity of vulnerability of human neurodegenerative and developmental diseases, in particular ALS / motor neuron disease, HSPs, PLS, Huntington’s disease, autism spectrum disorders (ASD), and Rett syndrome and ACC in particular of ASDs.