We are delighted to have Mario Capecchi return to Harvard as the Paul Doty Lecturer. Mario completed his PhD. in the Biological Laboratories in 1967 with Jim Watson in the joint laboratory of Jim Watson and Wally Gilbert.
For his thesis Mario discovered protein factors that mediate the release of completed polypeptide chains during protein synthesis. Mario was then appointed a Junior Fellow of the Society of Fellows and subsequently became an assistant professor at the Harvard Medical School.
He then moved to the University of Utah where he famously developed methods for creating knockout mutants of mouse genes and for which he was awarded the Nobel Prize in Medicine and Physiology.
Turning his attention to neurobiology, Mario recently discovered that defects in certain kinds of cells in the brain (Hoxb8 microglia) are responsible for chronic anxiety and compulsive behavior. The Lectureship is named in honor of Paul Doty, a much beloved member of our community.