The goals of The Sabeti Lab are to use computational methods and genomics to understand mechanisms of evolutionary adaptation in humans and pathogens. We are pursuing these goals through 3 research foci:
1. Developing analytical and experimental methods to detect and investigate natural selection in the genome of humans and other species.
2. Examining host and viral genetic factors driving resistance to Lassa Fever in West Africa.
3. Examining signals of natural selection in pathogens, including Lassa virus, Ebola virus, and Plasmodium falciparum malaria to understand how they rapidly evolve, and studying their genetic diversity to guide long term intervention strategies.