Lawrence J. Henderson Prize
The Henderson Prize honors the work of Professor Henderson (1878-1942), who began teaching at Harvard in 1905 and is best known for his research on blood biochemistry. The prize consists of a $500 book award, a framed certificate, and a copy of Dr. Henderson’s book, “Fitness of the Environment.” Each year a committee of the Board of Tutors in Biochemical Sciences reviews all theses that have been evaluated as outstanding (A) by both thesis readers. One (and occasionally two) students are awarded the Henderson Prize annually.
Henderson Prize Recipients:
2013 James Meixiong
The critical role of host lipid metabolism in determining the infectivity of Hepatitis C virus
2012 Stephanie Lin
Integration of the ER and oxidative stress responses through SKN-1
2012 Priscilla Wang
Netrin-1 Promotes Glioblastoma Invasion and Angiogenesis Through a Cathepsin B-Dependent Mechanism
2011 Siyuan (John) Liu and Yunsoo Kim
John’s thesis title is “Single Cell Temporal Dynamics and Spatial Reorganization of Oct4 in Mouse Embryonic Stem Cells Reveal Differential Activation of the Pluripotency Circuit During Cell Fate Selection”
Yunsoo’s thesis title is “A conserved cytoplasmic tyrosine kinase functions in the transport of silencing RNA between C. elegans cells”
2010 Daniel Bear and Laura Huppert
Dan’s thesis title is “Genome-wide and Single-cell Analysis of Neuronal Activity-regulated Gene Expression”
Laura’s thesis title is “Localization, Regulation, and Function of a First Type VII Protein Secretion System in Bacillus subtilis”
2009 Kaloyan Tsanov
An Embryonic Stem Cell Based System for Rapid Analysis of Developmentally Regulated Enhancer Elements
2008 Katie Rose Clapham
A Tiny Protein Links Two Morphogenetic Processes in a Bacterium
2007 Alisa Anne Mueller
I. Structural and Mechanistic Studies of TadA, an Adenosine Deaminase that Acts on tRNA
II. Structural and Biochemical Analysis of the C-terminal Domain of UvrC, a DNA Damage Repair Enzyme
2006 Milena Maria Andzelm
The Role of Myosin II in Natural Killer Cell Effector Function
2006 Shelly SeungAh Choo
Structural and Biochemical Studies of the N-Terminal Region of the Temperature-Sensing TRPV Ion Channels
2005 Sarah J. Hill
Characterization of a Novel Chromodomain Protein
2004 Rozalina Grubina
The Development of DNA-Templated Synthesis for the Creation and Discovery of Synthetic Small Molecules
2003 John Christian Huetsch
Crystal Structure of the DNA-wrapping Domain of DNA Gyrase A from Escherichia coli
2002 Narie J. Yoo
The Identification of Genes Involved in the Development of Streptomyces coelicolor.
2001 Jeffrey Lu
Characterization of Deletions Created by the Hybrid Mobile Element P {why}to Study Gene Function in Drosophilia Melanogaster.
2000 Ryan Edward Dorris
Tumor Cell Lines Resistant to Caspase-Mediated Apoptosis Are Sensitive to CTL Attack, Granzyme Loading, and UV Irradiation.
2000 James L. Young
The Serpin PI-9 is an Endogenous Inhibitor of Interleukin-1b-Converting Enzyme (Caspase-1) Activity in Human Vascular Smooth Muscle Cells.
1999 Timothy Yu-Ting Tseng
Biochemical Characterization of the Salmonella typhimurium Phage SP6 DNA Primase
1998 Aurelio A. Teleman
Studies on the Segregation and Architecture of the Bacterial Chromosome.
1997 Joshua Shulman
A Genetic Analysis of Drosophila Dishevelled Reveals Distinct Roles in Planar Polarity Specificati and Wingless Signal Transduction.
1996 Jeffrey Tong
Catalytic Mechanism of Fpg.
1995 Carl Aschkenasi
Isolation and Characterization of Six Drosophila Lines Mutant in the formation of the Retinotopic Map.
1995 Oliver Rando
Elucidation of the Mechanism of Activation of Nf- B: the Proteasome is Required for Processing of the 105Kd Nf- B1 Precursor and Degradation of I- B.
1994 Rojat Rohatgi
Non-emzymatic Template-directed Ligation Reactions of Ribo-oligonucleotides.
1993 Dan Barouch
Role of the Minor Coat Protein Vp3 in the Structural Organization of the Polyomavirus Capsid.
1993 Bernard Chang
The Functional Significance of the Cd4-T Cell Receptor Interaction.
1992 Andre Cheng
Does Haploinsufficiency of the Drosophila Ribosomal Protein Gene Rps4 Result in the Minute Phenotype?
1992 Ted Mau
Structure and Dynamics in Protein-dna Interaction: A Nuclear Magnetic Resonance Study of Gal4.
1991 Kathleen D. Liu
Structure Function Relationships of Triosephosphate Isomerase.
1990 Jayaraj Rajagopal
The Structure and Enzymatic Activity of the Tetrahymena Ribozyme.
1989 Paul A. Monach
Identification of a Putative Regulatory Gene for Defense Against Oxidative Damage in Escherichia Coli.
1988 Lucy Ann Godley
The Mutagenesis, Expression, and Characterization of Two Hemagglutinin Mutants.
1988 theodore S. Steiner
Voltage Clamp Studies of the Excitatory Response To Capsaicin in Pain Neurons.
1987 Calvin J. Kuo
Purification, Characterization and Modes of Activation of A Putative Growth- and Transformation-sensitive Ribosomal Protein S6 Kinase.
1986 Julie Nardone
Characterization of a Bradykinin Receptor by Binding of 3H-bradykinin.
1985 Seung K. Kim
Pp4 Virl Master Copy: A Novel Mechanism for Plasmid Establishment and Maintenance.
1984 Calvin Ho
Point Mutations in a Aminoterminal Fragment of Alanine Transfer Rna Synthetase Which Elevate Activity.
1984 Peter Sorger
The Self-assembly of Turnip Crinkle Virus, an Icosaherdral Rna Virus.
1983 Charles Cassidy
Modulatory Role for the Cholinergic Amacrine: Two Types of Acetylcholine Release in the Rabbit Retina.
1983 Albert C. Shaw
Sequence Dependence of the Helical Repeat of Dna in Solution.
1982 Judith Bender
Physical and Functional Properties of Brain Adenylate Cylase Catalytic Component.
1981 Se-Jin Lee
Altered Patterns of Gene Expression by Satellite P4 Mutants Unable to Regulate their P2 Helper.
1981 Juliann M. Paolicchi
Characterization of an Induction Sensitive Mutation in Bacteriophage Lambda.
1980 Christopher A. Kaiser
The Role of Lambda Dna Replication in the Transposition of Tn5.
1979 Thanh Van Huynh
A Walk Along the Bacillus Subtilis Chromosome in a Region Containing Developmentally-controlled Genes.
1979 Seth Jay Orlow
The Extracellular Cyclic Amp Phosphodiesterase of Dictyostelium Discoideum and its Interaction with its Inhibitor.
1978 Charles L. Diana
Studies on A Multigenomic Bacteriophage.
1978 Marcia M. Moore
An Investigation of the Metabolism of Tyrosine and Tyramine in the Central Nervous System of the Moth Manduca Sexta.
1977 David M. Shore
Head Size Determination of Icosahedral Viruses, the Isolation and Characterization of Satellite Bacteriophage P4 Mutant Affected in Head Size Determination.
1976 Dorothy Jessel
Studies on the Dna Binding of Sv40 T Antigen.
1975 Nicholas Cataldo
Studies on the Mechanism of Action of a Phospodiesterase.
1975 Stephen Rayport
Frog Skin Photoreceptors.
1974 Daniel Podolsky
Concanavalin A Agglutination.
Honorable Mention: Donald Kennerly
Idiotypic Analysis of Antibodies Present During the 37 Week Immune Response of a Single Rabbit.
1973 Perrin Charles
Molecular Mechanism of Nonspecific Permeation Through Lipid Membranes.
Honorable Mention: Jane Robin Parnes
Energy Coupling in the B-methylgalactoside Transport System of Escherichia Coli.
1971 Heng Soon Tan
Studies in the Binding of Neurophysin to Vasopressin.