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Molecular and neural architecture of social behavior circuits
High resolution dynamic and spatial studies of prokaryotic cellular organization
Role of the retinoblastoma protein (pRB) pathway in differentiation and cancer
C. elegans genetics of intercellular RNAi signaling
Development of chemical and molecular biology tools to allow new measurements and perturbations in biological systems; study mechanisms of gene regulation and dysregulation in cancer.
Microbial development and gene regulation
Development and application of chemical proteomic methods to study the interactions of therapeutics, natural products, and metabolites within the cellular proteome