(l) Andres Leschziner and Michael Cianfrocco Structural biology is currently undergoing a revolution: single-particle cryo-electron microscopy (cryo-EM) has recently realized its potential for routinely determining the structures of…
Tag: Publication
WIRED TO ESCAPE [SCHIER AND ENGERT LABS]
(l) Alex Schier, and Alix Lacoste Knock on a tank of fish and you may observe that the animals suddenly change position. Blink, and you missed it. When…
THE WHERE AND WHY OF GENE EXPRESSION [SCHIER LAB]
(l to r) Jeff Farrell, Alex Schier, and Julien Dubrulle While most cells in the body have the same DNA, and thus the same set of genes, cells…
WHY SOME AXONS REGENERATE BETTER THAN OTHERS [SANES LAB]
Recovery from injury to the mammalian brain or spinal cord is notoriously poor, and a big part of the problem lies in the limited ability of damaged neurons…
CLOCK GENES TIME BRAIN DEVELOPMENT [HENSCH LAB]
Scientists have long known that humans and other animals have a master biological clock situated in a deep brain region called the hypothalamus. In this master clock, cells…
FEELING GOOD OR BAD LATELY? LISTEN TO SEROTONIN [UCHIDA LAB]
(l to r) Mackenzie Amoroso, Jeremiah Cohen, and Nao Uchida Serotonin is one of the most widespread and mysterious neurotransmitters in the brain. It has been proposed to…
A ROTARY MOTOR FOR BACTERIAL GLIDING [BERG LAB]
(l to r) Howard Berg, Abhishek Shrivastava, and Pushkar Lele Bacterial gliding is defined as steady movement over a surface, of bacteria that have neither flagella nor pili. …
ONE SMALL TWEAK CONVERTS A TRANSPORTER FROM A ONE-WAY INTO A TWO-WAY STREET [GAUDET LAB]
Ahmet Vakkasoglu (l) and Rachelle Gaudet At the heart of our adaptive immune system is the presentation of internal antigens, usually peptides, to cytotoxic T cells. The Transporter…
LIS1 [LESCHZINER LAB]
(l to r) Kat Toropova, Andres Leschziner,Sam Reck-Peterson, Sirui Zou and (front row) Locksley Cytoskeletal motors are molecular machines that “walk” along the filaments that provide structural support…
RNA REMODELING BY AN EFFICIENT RETROVIRAL RENOVATOR [D’SOUZA LAB]
As anyone who has renovated a home knows, the process of remodeling often requires an elaborate orchestration of timing and materials. Remodeling at the molecular level is likewise…
