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News from 2007

MICRORNAS AND NODAL SIGNALING

Authors Wen-Yee Choi, Antonio Giraldez (on screen), and Alex Schier MicroRNAs are small RNAs that bind to specific mRNAs and inhibit their translation. Hundreds of microRNAs are thought…

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FEMALE AND MALE MICE SEXUAL BEHAVIORS ARE JUST A SNIFF AWAY

Authors Jennings Xu, Catherine Dulac, and Tali Kimchi In rodents, as in most vertebrates, the social and sexual behaviors of males and females clearly differ. For example, female…

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RICHARD LOSICK “FEEDS” STUDIES IN SCIENCE

Professor Richard Losick (front row, center), Professor Catherine Dulac (far right), Dr. Michelle McMurray ’91 (second row, next to Professor Dulac) and the HHMI research students at the…

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SWITCHING ON BRAIN-SPECIFIC ALTERNATIVE SPLICING WITH A MICRORNA

Jiangwen Zhang, Monica Carrasco, Eugene Makeyev and Tom Maniatis Cellular differentiation requires global changes in gene expression at both transcriptional and posttranscriptional levels. Posttranscriptional regulation provides a mechanism…

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CATHERINE DULAC’S PHENOMENAL PHEROMONE FASCINATION

Catherine Dulac The brain’s cognitive abilities fascinate most people in neuroscience, but Catherine Dulac is drawn to the non-cerebral, genetically encoded, instinctive behaviors on which an animal’s very…

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RACHELLE GAUDET AWARDED KLINGENSTEIN FELLOWSHIP

Rachelle Gaudet Rachelle Gaudet has been selected to receive a Klingenstein Fellowship Award in the Neurosciences for 2007 for her project, "Structural biology of temperature sensing by the…

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STATE OF THE ART

Wormopoly creators (left to right) Jacqueline Brooks, Casey Roehrig, Nina Rajpurohit and Deborah de Jong. Jessica Smith not pictured. Cookie-scope The 16th International C. elegans Meeting was held…

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GIVING HEDGEHOG THE GAS: IDENTIFICATION OF GAS1 AS A NOVEL POSITIVE COMPONENT OF SHH SIGNALING

Authors Ben Allen (left) and Andy McMahon Hedgehog (Hh) proteins are secreted morphogens that act in a concentration depependent manner to shape numerous developmental processes.  The effects of…

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FINE-TUNING HEAT SENSITIVITY

This illustration is a surface representation of the TRPV1ankyrin repeat structure (in green) with a bound ATP molecule (multicolor sticks) on a background of capsaicin-laden red pepper flakes.…

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