This year, James M Berger, of Johns Hopkins University School of Medicine will return to Harvard to present the Doty Lecture, “Still Unscrambling the Puzzle of Biological Machines:…
Work spearheaded by post-doctoral fellow Tadasu Nozaki, in the Kleckner laboratory, and recently published in Nature (PDF), uses a powerful new approach to examine pairing of homologous chromosomes…
On Thursday November 30, Scott Keeney of Memorial Sloan Kettering (MSK) Cancer Center and HHMI investigator will deliver the 2023 Paul Doty Lecture. Named for MCB professor Paul…
Researchers from the Kleckner Lab, in collaboration with researchers at CNRS in France and the Chinese Academy of Sciences, have found evidence that microscopic “inter-axis bridges,” which form…
Inheritance at the cellular level rests on the fact that one progenitor cell produces two identical daughter cells. The chromosomes are replicated and then, for each chromosome, the…
The genomes of most eukaryotic organisms, including humans, contain large amounts of repetitive DNA organized in the form of heterochromatin. As a result, this specialized chromatin state plays…
Sexual reproduction involves the production of male and female gametes (e.g. sperm and egg) each of which carries a single complete set of chromosomes. In most organisms, this…
The Genetics Society of America (GSA) has awarded Nancy Kleckner, the Herchel Smith Professor of Molecular Biology in the Department of Molecular and Cellular Biology, the 2016 Thomas…
We have suggested that chromosomes should be viewed as macroscopic mechanical objects whose functions are governed by accumulation, release and redistribution of mechanical stress. We have proposed specifically…
(l to r) Shunxin Wang, Nancy Kleckner, Liangran Zhang, and Shen Yin Gamete formation for sexual reproduction involves the specialized cellular program of meiosis. As part of this…
