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Tag: Nancy Kleckner

A New View of Mitotic Chromosomes [Kleckner Lab]

Inheritance at the cellular level rests on the fact that one progenitor cell produces two identical daughter cells.  The chromosomes are replicated and then, for each chromosome, the…

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Pairing Off to Work: Nucleating Gene Silencing by Direct Interactions of Homologous Double-stranded DNA Molecules [Kleckner Lab]

The genomes of most eukaryotic organisms, including humans, contain large amounts of repetitive DNA organized in the form of heterochromatin. As a result, this specialized chromatin state plays…

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The Case of the Missing Crossovers [Kleckner Lab]

Sexual reproduction involves the production of male and female gametes (e.g. sperm and egg) each of which carries a single complete set of chromosomes. In most organisms, this…

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NANCY KLECKNER HONORED WITH 2016 THOMAS HUNT MORGAN MEDAL

The Genetics Society of America (GSA) has awarded Nancy Kleckner, the Herchel Smith Professor of Molecular Biology in the Department of Molecular and Cellular Biology, the 2016 Thomas…

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CHROMOSOMES AS MECHANICAL OBJECTS [KLECKNER LAB]

We have suggested that chromosomes should be viewed as macroscopic mechanical objects whose functions are governed by accumulation, release and redistribution of mechanical stress.  We have proposed specifically…

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SPATIAL PATTERNING OF MEIOTIC CROSSOVERS: A CENTURY-OLD MYSTERY [KLECKNER LAB]

(l to r) Shunxin Wang, Nancy Kleckner, Liangran Zhang, and Shen Yin Gamete formation for sexual reproduction involves the specialized cellular program of meiosis.  As part of this…

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LOOK MOM, NO BREAKS! [KLECKNER LAB]

Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage and recombination.  The genome-wide synapsis of…

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HOW DOES E. COLI SEGREGATE ITS SISTERS WITHOUT A SPINDLE? [KLECKNER LAB]

(l to r) Guillaume Witz, Mara Prentiss, Nancy Kleckner, Beth Weiner, and Jay K. Fisher The E. coli chromosome is a single circular unit which, if stretched out,…

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NEW COURSE: MCB 144 [PROF. NANCY KLECKNER AND PROF. DAVID HAIG]

Meeting Time: M., W., 12:00 pm  – 1:30 pmLocation: Northwest Building 169 (Harvard Square-distal end of first floor hallway)Prerequisites: Suitable for students in either the physical or biological…

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HOW TO FIND YOUR HOMOLOG WITHOUT LOSING YOUR SISTER

Meiosis is a modified cellular program by which a single diploid cell gives rise to haploid gametes (e.g. sperm and egg). To this end, DNA replication is followed…

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