Andrew Murray and Vahan Indjeian Errors in chromosome segregation lead to disease and death. To prevent such errors, sister chromatids are held together with the protein complex cohesin,…
View Movies and Figures A 360° view of a segregated neuromuscular junction (muscle surface is shown in red). The animation provides a closeup of the green bulb-tipped axon…
The image shows a pair of adjacent sporangia each of which consists of a large mother-cell (green) and a forespore (circular chambers outlined in red). The green color…
A paper in the August 24 issue of Proceedings of the National Academy of Sciences, U.S.A., from the Kleckner lab provides a new theory of chromosome function that…
Biological systems are robust; they function reliably despite disruptions. Internal fluctuations occurring on a microscopic scale or changes in external conditions, such as temperature, pose challenges to system…
Neurons analyze and transmit information in the brain. Information is transferred from one neuron to another through the functional contact sites called synapses. When a neuron is activated,…
G. Valentin Boerner Nancy Kleckner Neil Hunter Meiosis is the modified cellular program by which a diploid cell produces haploid gametes as required for sexual reproduction. A key…
Coauthors: Professor Andy McMahon, graduate student Juhee Jeong, postdoctoral fellow Junhao Mao, and postdoctoral fellow Toyoaki Tenzen. Another coauthor, Assistant Professor Andreas H. Kottmann of Columbia University, New…
There has been enormous excitement in recent years about adult stem cells, ignited by reports that highlighted their plasticity and potential therapeutic use. Adult stem cells are clearly…