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Tag: Science

CHANGING THE CULTURE OF SCIENCE EDUCATION AT RESEARCH UNIVERSITIES

Rich Losick Professors at large research universities have two important responsibilities: generating new knowledge and educating students. Sometimes these missions are seen as being in competition. Indeed, we…

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REMOVING AN ENDOGENOUS PROTOTOXIN RESTORES VISION

(L to R) Hirofumi Morishita and Takao K. Hensch Much of our behavior reflects the neural circuits sculpted by experience during early developmental critical periods. Such heightened brain…

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A SMALL MOLECULE TRIGGER FOR BIOFILM DISASSEMBLY

A three-way collaboration between the laboratories of Rich Losick in MCB and Roberto Kolter and Jon Clardy at Harvard Medical School has led to the discovery of a…

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PREDICTING DRUG TARGETS BY WATCHING ZEBRAFISH SLEEP

(L to R)Alexander Schier and Jason Rihel Many psychiatric drugs were discovered decades ago through serendipity. For example, a tuberculosis drug called iproniazid also happened to make people…

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A ROLE FOR MICRORNAS IN AMYOTROPHIC LATERAL SCLEROSIS

(L to right) Gregorio Valdez and Joshua R. Sanes The great baseball player, Lou Gehrig, gave his name to the neurodegenerative disease that killed him, Amyotrophic Lateral Sclerosis.…

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GEOMETRIC CUE FOR PROTEIN LOCALIZATION

Kumaran S. Ramamurthi and Richard Losick Although bacteria are much more architecturally simple than eukaryotic cells, it has been evident for over a decade now that they are…

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WNTS ON THE BRAIN: REQUIREMENT OF WNT SIGNALING IN CNS VASCULATURE DEVELOPMENT

(L to R) Andy McMahon and Jan Stenman All tissues in our bodies require blood vessels for oxygen and nutrients. While all vasculature share certain features, their formation…

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A NEURAL CODE BASED ON SPIKE TIMING IN THE RETINA

Co-authors (L to R): Tim Gollisch and Markus Meister The process of vision begins in the retina. This neuronal network at the back of the eyeball receives incident…

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MULTISITE PHOSPHORYLATION AND CIRCADIAN OSCILLATIONS

Left to right: Michael J. Rust, Erin K. O'Shea, and Joseph S. Markson Circadian rhythms are daily cycles of behavior and metabolism that allow organisms to anticipate the…

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MICRORNAS AND NODAL SIGNALING

Authors Wen-Yee Choi, Antonio Giraldez (on screen), and Alex Schier MicroRNAs are small RNAs that bind to specific mRNAs and inhibit their translation. Hundreds of microRNAs are thought…

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