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Tag: Sharad Ramanathan

Learning to Grow “Neural Tubes” In Vitro Yields Insights Into Human Embryonic Development [Ramanathan Lab]

Researchers in the Ramanathan Lab asked how the human embryo – and in particular an embryonic tissue called the neural tube, which gives rise to the spinal cord…

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Directed Morphogenesis of Early Human Spinal Cord and Locomotor System [Ramanathan Lab]

A study from the Ramanathan Lab, helmed by graduate student Yusuf Ilker Yaman, has shed light on how developing human embryos take shape. The paper appears in the…

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For Signaling Receptors, Location Matters [Ramanathan Lab]

For embryos to develop properly, cells must communicate with one another over long ranges through diffusive chemical signals called morphogens. These signals act as instructive cues for the…

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Finding a Neuron in a Haystack [Ramanathan Lab]

A fundamental question in neuroscience is how neural networks generate behavior. The first challenge in answering this question is to identify neurons and circuits controlling the behavior of…

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Sharad Ramanathan Co-director of New Quantitative Biology Initiative

QUANTITATIVE BIOLOGY INITIATIVE website, Sharad Ramanathan faculty profile,  Ramanathan lab

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Finding Sparse Patterns in High Dimensional Single Cell Gene Expression Data [Ramanathan Lab]

During development, multipotent cells make a series of cell fate decisions, eventually leading to the various distinct cell types in the body. With the advent of high-throughput measurement…

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Early Germ Layer Differentiation Occurs Through a Series of Discrete Cell State Transitions [Ramanathan Lab]

During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…

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Uncovering the Dynamics of Interneuron Production and Maturation [Ramanathan Lab]

Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…

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Student Publishes Book on Systems Biology

James Valcourt, a third-year PhD student in Sharad Ramanathan’s lab, has written and published a book for the popular science market. Systematic: How Systems Biology Is Transforming Modern…

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Human brain cells begin their lives as pluripotent cells with the potential to develop into any cell type in the body. As those pluripotent stem cells differentiate and…

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