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For embryos to develop properly, cells must communicate with one another over long ranges through diffusive chemical signals called morphogens. These signals act as instructive cues for the…
A fundamental question in neuroscience is how neural networks generate behavior. The first challenge in answering this question is to identify neurons and circuits controlling the behavior of…
QUANTITATIVE BIOLOGY INITIATIVE website, Sharad Ramanathan faculty profile, Ramanathan lab
During development, multipotent cells make a series of cell fate decisions, eventually leading to the various distinct cell types in the body. With the advent of high-throughput measurement…
During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…
Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…
James Valcourt, a third-year PhD student in Sharad Ramanathan’s lab, has written and published a book for the popular science market. Systematic: How Systems Biology Is Transforming Modern…
Human brain cells begin their lives as pluripotent cells with the potential to develop into any cell type in the body. As those pluripotent stem cells differentiate and…
The surface of the human brain has many folds (is gyrified), quite unlike the smooth surface of the mouse brain. This gyrification correlates with the increase in size…
(l to r) Sharad Ramanathan, Sumin Jang (G4, MCO), Ching-Han (Hannah) Shen (G6, MCO), Jeffrey Lee (G5, Applied Physics), Leon Furchtgott (G5, Biophysics), Abdullah Yonar (G1, Applied Physics),…
