Researchers in the Ramanathan Lab asked how the human embryo – and in particular an embryonic tissue called the neural tube, which gives rise to the spinal cord…
Tag: Sharad Ramanathan
Directed Morphogenesis of Early Human Spinal Cord and Locomotor System [Ramanathan Lab]
A study from the Ramanathan Lab, helmed by graduate student Yusuf Ilker Yaman, has shed light on how developing human embryos take shape. The paper appears in the…
For Signaling Receptors, Location Matters [Ramanathan Lab]
For embryos to develop properly, cells must communicate with one another over long ranges through diffusive chemical signals called morphogens. These signals act as instructive cues for the…
Finding a Neuron in a Haystack [Ramanathan Lab]
A fundamental question in neuroscience is how neural networks generate behavior. The first challenge in answering this question is to identify neurons and circuits controlling the behavior of…
Sharad Ramanathan Co-director of New Quantitative Biology Initiative
QUANTITATIVE BIOLOGY INITIATIVE website, Sharad Ramanathan faculty profile, Ramanathan lab
Finding Sparse Patterns in High Dimensional Single Cell Gene Expression Data [Ramanathan Lab]
During development, multipotent cells make a series of cell fate decisions, eventually leading to the various distinct cell types in the body. With the advent of high-throughput measurement…
Early Germ Layer Differentiation Occurs Through a Series of Discrete Cell State Transitions [Ramanathan Lab]
During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…
Uncovering the Dynamics of Interneuron Production and Maturation [Ramanathan Lab]
Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…
Student Publishes Book on Systems Biology
James Valcourt, a third-year PhD student in Sharad Ramanathan’s lab, has written and published a book for the popular science market. Systematic: How Systems Biology Is Transforming Modern…
FINDING FORKS IN THE ROAD OF HUMAN BRAIN DEVELOPMENT [RAMANATHAN LAB]
Human brain cells begin their lives as pluripotent cells with the potential to develop into any cell type in the body. As those pluripotent stem cells differentiate and…
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