Department News News Archive

News archive

Tag: Publication

Go Against the Flow [Engert Lab]

Understanding brain function generally requires a deep engagement with the matter at least at two separate levels. These are the level of behavioral algorithms on the one hand…

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The First Nanoscale Rendering of an Entire Vertebrate Brain

People frequently operate computer devices such as smartphones that collect user input and process this information to produce outputs on a display or through headphones.  Engineers control how…

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Pairing Off to Work: Nucleating Gene Silencing by Direct Interactions of Homologous Double-stranded DNA Molecules [Kleckner Lab]

The genomes of most eukaryotic organisms, including humans, contain large amounts of repetitive DNA organized in the form of heterochromatin. As a result, this specialized chromatin state plays…

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Do Not Go Rhythmless into That Good Night [O’Shea Lab]

The cycle of day and night is one of the most recurrent and predictable environmental change on our planet. Consequently, organisms evolved mechanisms that give them an ability…

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Good Parent, Bad Parent: The Evolution of Parental Care in Monogamous Mice [Hoekstra and Dulac Labs]

Parental care is crucial for the survival of mammals, yet species vary widely in the extent and type of care they give to their young. In species where…

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Who Moved My Arm? Learning from Performance Error [Uchida Lab]

You head to your favorite coffee shop, order a cappuccino, and when the barista calls your name, you grab your coffee. Imagine, however, you grab the wrong cup…

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Finding Sparse Patterns in High Dimensional Single Cell Gene Expression Data [Ramanathan Lab]

During development, multipotent cells make a series of cell fate decisions, eventually leading to the various distinct cell types in the body. With the advent of high-throughput measurement…

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From Motion to Mechanism: Cytoskeletal Dynamics Drive Cell Division in Bacteria [Garner Lab]

Cell division is one of the most fundamental processes of life, conserved across all kingdoms. Over the last decades, scientists have identified many of the components involved in…

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Early Germ Layer Differentiation Occurs Through a Series of Discrete Cell State Transitions [Ramanathan Lab]

During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…

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Uncovering the Dynamics of Interneuron Production and Maturation [Ramanathan Lab]

Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…

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