During mammalian development, embryonic stem cells undergo cell-fate decisions to commit to one of three germ layer lineages: ectoderm, mesoderm and endoderm. Although decades of research in developmental…
Tag: Publication
Uncovering the Dynamics of Interneuron Production and Maturation [Ramanathan Lab]
Inhibitory interneurons are a diverse population with crucial roles in cortical and striatal information processing. These cells have been implicated in human neuropsychiatric and neurodevelopmental disorders, including autism,…
The Case of the Missing Crossovers [Kleckner Lab]
Sexual reproduction involves the production of male and female gametes (e.g. sperm and egg) each of which carries a single complete set of chromosomes. In most organisms, this…
Prediction Errors Stay on Track, Even When the Ride is Unpredictable [Uchida Lab]
Imagine you are waiting for the 2PM subway train. Based on your experience, you know that the train always arrives between 1:55PM and 2:05PM. You glance at your…
Unusual Calcium Binding Allows Flexing of a Cadherin Involved in Hearing [Gaudet Lab]
Vertebrates rely on the inner ear to convert the mechanical stimuli of sound and head movements into electrical signals that can be decoded by the brain. This process,…
Inheritance of Epigenetic Information [Hunter Lab]
RNA interference (RNAi) in C. elegans is remarkably potent and efficient. It is potent because minuscule amounts of RNA silencing signals can be amplified and it is efficient…
WHAT’S ON THE NEWS? DOPAMINE BROADCASTS MULTIPLE TYPES OF INFORMATION [Uchida Lab]
Monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline are released by small populations of neurons that send information to much of the brain. These neurons function like major…
INSIGHTS INTO CAUSES OF ANEMIA FROM A MEMBRANE PROTEIN STRUCTURE [GAUDET LAB]
Iron is a key micronutrient that organisms use in many biological processes. Indeed, aerobic respiration requires iron to transport oxygen in our blood, to catalyze redox reactions of…
NEW STRUCTURAL RNAS? NOW WE CAN TELL [RIVAS AND EDDY LABS]
Some fundamental cellular activities are directed by RNA-based machines. The RNAs in these machines adopt distinct three-dimensional structures in order to facilitate their function, much in the way…
NEURAL CIRCUITS AT THE BRAIN SCALE [ENGERT LAB]
A longstanding goal of neuroscience is to figure out how the brain reacts to what is happening in the outside world. But it has been challenging to map…
