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Tag: Publication

RETINAL GANGLION CELLS RAPIDLY CHANGE POLARITY

Authors (left to right) Maria Neimark Geffen, Saskia E. J. de Vries and Markus Meister The eye communicates to the brain all the information needed for vision in…

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PUTTING A FACE ON A CLASS OF VIRAL DEUBIQUITINATING ENZYMES

(l to r) Authors Wilhelm Weihofen, Rachelle Gaudet and Christian Schlieker Herpesviruses (members of the Herpesviridae family) are widespread pathogens, causing disease in humans and animals. The family…

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YANKING THE CHAIN: PULLING ON BACTERIAL FLAGELLA TO TRIGGER POLYMORPHIC TRANSFORMATIONS

Authors Howard C. Berg & Nicholas C. Darnton In many of the bacteria that swim by rotating helical flagella, the flagellum itself is not a simple, passive propeller.…

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IKΒ KINASE IKKΕ PLAYS CRITICAL ROLE IN ANTIVIRAL INNATE IMMUNITY

Left to right: Authors Benjamin tenOever, Tom Maniatis and Sze-Ling Ng Innate immunity is the first line of defense against infectious microorganisms. When we are infected by flu…

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TAP’S TWO-CYLINDER ENGINE

Authors Ian Errin-O'Connell, Eik Procko, Sze-Ling Ng and Rachelle Gaudet In nearly all human cells, TAP, the ABC Transporter associated with Antigen Processing, transports small antigen peptides across…

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SWITCHING OFF A CELL CYCLE CHECKPOINT

A model for feedback control of spindle checkpoint activity Feedback control of spindle checkpoint activity. (Left) Prior to metaphase, chromosomes that are incorrectly aligned on the mitotic spindle…

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BAD TO THE BONE: UNLOCKING THE MOLECULAR REGULATION OF OSTEOBLAST DIFFERENTIATION AND BONE SYNTHESIS

Co-authors Andy McMahon (left) and Stephen Rodda The mammalian skeleton is important for many physiological functions; as a scaffold, it supports the body, enabling motion and mechanical loading,…

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