(L to R): Jochen Utikal, Matthias Stadtfeld, Nimet Maherali, Konrad Hochedlinger, Sarah Eminli, and Katrin Arnold Nuclear transfer experiments, such as the cloning of Dolly the sheep, have…
Tag: Publication
CHIPPING AWAY AT HEDGEHOG-MEDIATED NEURAL PATTERNING
Co-authors (left to right): Hongkai Ji, Steven Vokes, Andrew McMahon and Wing H. Wong The Hedgehog signaling pathway represents one of approximately six major families of signaling pathways…
A KINASE PATHWAY REQUIRED FOR NEURONAL POLARITY
Authors Josh Sanes (left) and Brendan Lilley Directional flow of information within the nervous system depends upon the ability of neurons to divide themselves into discrete compartments. Most…
NEURODEGENERATION IN A PETRI-DISH: AN EMBRYONIC STEM CELL MODEL FOR ALS
Authors (left to right): Francesco DiGiorgio, Monica Carrasco, Tom Maniatis, Michelle Siao, Kevin Eggan Amyotrophic Lateral Sclerosis, also known as ALS or Lou Gehrig’s disease, is a devastating…
REGULATION OF CYCLIN-CDK ACTIVITY BY INOSITOL PYROPHOSPHATES
Authors Erin K. O'Shea (left) and Recent work by the O’Shea lab offers new insight into metabolic processes. Cell metabolism engenders many secondary products, metabolites, that play crucial…
TARGET-DERIVED SIGNALS ORGANIZE MOTOR NERVE TERMINALS
Authors Michael Fox (left) and Josh Sanes The synapse is the heart of the nervous system, the site at which information is processed and passed between cells. Proper…
RETINAL GANGLION CELLS RAPIDLY CHANGE POLARITY
Authors (left to right) Maria Neimark Geffen, Saskia E. J. de Vries and Markus Meister The eye communicates to the brain all the information needed for vision in…
PUTTING A FACE ON A CLASS OF VIRAL DEUBIQUITINATING ENZYMES
(l to r) Authors Wilhelm Weihofen, Rachelle Gaudet and Christian Schlieker Herpesviruses (members of the Herpesviridae family) are widespread pathogens, causing disease in humans and animals. The family…
YANKING THE CHAIN: PULLING ON BACTERIAL FLAGELLA TO TRIGGER POLYMORPHIC TRANSFORMATIONS
Authors Howard C. Berg & Nicholas C. Darnton In many of the bacteria that swim by rotating helical flagella, the flagellum itself is not a simple, passive propeller.…
IKΒ KINASE IKKΕ PLAYS CRITICAL ROLE IN ANTIVIRAL INNATE IMMUNITY
Left to right: Authors Benjamin tenOever, Tom Maniatis and Sze-Ling Ng Innate immunity is the first line of defense against infectious microorganisms. When we are infected by flu…
