Jiangwen Zhang, Monica Carrasco, Eugene Makeyev and Tom Maniatis Cellular differentiation requires global changes in gene expression at both transcriptional and posttranscriptional levels. Posttranscriptional regulation provides a mechanism…
Authors Ben Allen (left) and Andy McMahon Hedgehog (Hh) proteins are secreted morphogens that act in a concentration depependent manner to shape numerous developmental processes. The effects of…
This illustration is a surface representation of the TRPV1ankyrin repeat structure (in green) with a bound ATP molecule (multicolor sticks) on a background of capsaicin-laden red pepper flakes.…
L to R: Garrett Birkhoff, Dieter Egli, Jacqueline Rosains and Kevin Eggan Ten years ago, the cloning of Dolly the sheep confirmed that the mamalian egg (oocyte), possesses…
(L to R): Jochen Utikal, Matthias Stadtfeld, Nimet Maherali, Konrad Hochedlinger, Sarah Eminli, and Katrin Arnold Nuclear transfer experiments, such as the cloning of Dolly the sheep, have…
Co-authors (left to right): Hongkai Ji, Steven Vokes, Andrew McMahon and Wing H. Wong The Hedgehog signaling pathway represents one of approximately six major families of signaling pathways…
Authors Josh Sanes (left) and Brendan Lilley Directional flow of information within the nervous system depends upon the ability of neurons to divide themselves into discrete compartments. Most…
Authors (left to right): Francesco DiGiorgio, Monica Carrasco, Tom Maniatis, Michelle Siao, Kevin Eggan Amyotrophic Lateral Sclerosis, also known as ALS or Lou Gehrig’s disease, is a devastating…
Authors Erin K. O'Shea (left) and Recent work by the O’Shea lab offers new insight into metabolic processes. Cell metabolism engenders many secondary products, metabolites, that play crucial…
Authors Michael Fox (left) and Josh Sanes The synapse is the heart of the nervous system, the site at which information is processed and passed between cells. Proper…
