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Tag: Publication

DULAC LAB: SMALL RNAS AND THE SENSE OF SMELL

Modern genetics textbooks highlight the concept of the ‘central dogma’ which states that DNA is transcribed into messenger RNA (mRNA) and that mRNA is subsequently translated into proteins. …

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MEISTER LAB: THE EYE HAS A SHORT ATTENTION SPAN

No matter how hard we fix our gaze, our eyes are in constant motion due to involuntary head and eye movements. The resulting image motion on our retinas…

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TECHNICOLOR BRAINS: MAPPING NEURAL CIRCUITS IN “BRAINBOW” MICE

More than a century ago, Ramón y Cajal’s use of Golgi staining to visualize nerve cells opened the door to modern neurobiology: by staining a small number of…

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GELBART LAB: GENOME ANALYSIS OF TWELVE DROSOPHILA SPECIES

(L to R): Kyl Myrick, Rob Kulathinal, Beverley Matthews, Lynn Crosby, Kenneth Wiley, Bill Gelbart, Jerry Antone, Sian Gramates Susan Russo and AJ Bhutkar On Thursday, November 8,…

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MULTISITE PHOSPHORYLATION AND CIRCADIAN OSCILLATIONS

Left to right: Michael J. Rust, Erin K. O'Shea, and Joseph S. Markson Circadian rhythms are daily cycles of behavior and metabolism that allow organisms to anticipate the…

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MICRORNAS AND NODAL SIGNALING

Authors Wen-Yee Choi, Antonio Giraldez (on screen), and Alex Schier MicroRNAs are small RNAs that bind to specific mRNAs and inhibit their translation. Hundreds of microRNAs are thought…

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FEMALE AND MALE MICE SEXUAL BEHAVIORS ARE JUST A SNIFF AWAY

Authors Jennings Xu, Catherine Dulac, and Tali Kimchi In rodents, as in most vertebrates, the social and sexual behaviors of males and females clearly differ. For example, female…

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SWITCHING ON BRAIN-SPECIFIC ALTERNATIVE SPLICING WITH A MICRORNA

Jiangwen Zhang, Monica Carrasco, Eugene Makeyev and Tom Maniatis Cellular differentiation requires global changes in gene expression at both transcriptional and posttranscriptional levels. Posttranscriptional regulation provides a mechanism…

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GIVING HEDGEHOG THE GAS: IDENTIFICATION OF GAS1 AS A NOVEL POSITIVE COMPONENT OF SHH SIGNALING

Authors Ben Allen (left) and Andy McMahon Hedgehog (Hh) proteins are secreted morphogens that act in a concentration depependent manner to shape numerous developmental processes.  The effects of…

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