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Tag: Publication

DECODING REGULATORY CIRCUITRY IN MAMMALIAN LIMB DEVELOPMENT

Co-authors (left to right): Hongkai Ji, Steven Vokes, Andrew McMahon and Wing H. Wong The vertebrate limb has been one of the central models for understanding the problem…

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PERCEIVING SMELLS WITH SPARSE CONNECTIONS

Many regions of the brain are organized in such a way that they form an ordered representation of our sensory experiences. Similar physical stimuli –nearby points of light…

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ENGINEERING BINOCULARITY IN THE ZEBRAFISH BRAIN

(left panel) Monocular retinal innervation in a normal larval zebrafish. The right optic tectal lobe receives input solely from the contralateral (red) retina. (right panel) Following rewiring, the…

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TRIGGER FOR BRAIN PLASTICITY IDENTIFIED

(L to R) Sayaka Sugiyama and Takao Hensch Researchers have long sought a factor that can trigger the brain’s ability to learn – and perhaps recapture the “sponge-like”…

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SELF-RENEWAL IN THE KIDNEY: A DEVELOPING STORY

(L to R) Andy McMahon, Todd Valerius, Josh Mugford, and Akio Kobayashi The kidney is a remarkable organ. Its actions maintain an appropriate water/salt balance within tissue fluids,…

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PIGGY-BACKING MEIOTIC CHROMOSOMES

The co-authors (left to right): M. Prentiss, R. Koszul, K.P. Kim, S. Kameoka, and N. Kleckner Movement plays important fundamental roles in basic chromosomal processes. Motion is most…

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WATCHING SYNAPSES CHANGE IN ANIMALS

Some of the authors (left to right): Corey M McCann, Juan Carlos Tapia, and Jeff W Lichtman Image shows submandibular ganglion neurons (blue) that express Cyan Fluorescent Protein…

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ASTROCYTES SPY ON NEURONAL CONVERSATION TO BRING A RUSH OF BLOOD TO THE HEAD

The human brain represents approximately 2% of the total body weight, but accounts for about 20% of the energy consumed. Functional hyperemia (local increases in blood flow triggered…

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CHROMATIN — A ONE-STOP ENGINEERING SOLUTION FOR COMPACTING DNA AND PARAMETERIZING GENE BEHAVIOR

Erin O'Shea, and Felix Lam If stretched end-to-end, the DNA inside a single human cell would measure approximately 2-3 meters. A fiber of this length is physically compacted…

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SMALL BUT MIGHTY

In a behaving animal, the brain processes information from sensory inputs, and communicates its intentions to muscles via the pattern of activity in descending projection neurons. In vertebrates,…

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