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Tag: Publication

A STRUCTURAL MODEL FOR THE DNA DAMAGE SENSOR IN BACTERIAL NUCLEOTIDE EXCISION REPAIR

(L to R) David Jeruzalmi, Danaya Pakotiprapha, and Gregory L. Verdine Genomic DNA is under a constant attack by various damaging agents.  Left uncorrected, such damage can lead…

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CONNECTOMICS

Ju Lu and Jeff Lichtman It is widely believed that in order to understand how the nervous system works, one needs to know where neural processes go and…

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HOW NOT TO WEAR OUT A WELCOME

Seung-Hwan Kim and Matthew Michael Just as dinner party guests who linger at the table long after coffee and dessert can strain the patience of their hosts, an…

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WNTS ON THE BRAIN: REQUIREMENT OF WNT SIGNALING IN CNS VASCULATURE DEVELOPMENT

(L to R) Andy McMahon and Jan Stenman All tissues in our bodies require blood vessels for oxygen and nutrients. While all vasculature share certain features, their formation…

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DISSECTING TRANSCRIPTIONAL NETWORK STRUCTURE AND FUNCTION

Andrew Capaldi and Erin O'Shea The gene expression program in a cell is set in response to the level, timing and combination of hundreds of developmental and environmental…

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A QUANTITATIVE MODEL OF TRANSCRIPTION FACTOR–ACTIVATED GENE EXPRESSION

Erin O'Shea, and Harold Kim One of the main challenges in the postgenomic era is to understand how genetic information is translated into quantitative transcriptional output. Transcription factors…

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DECODING REGULATORY CIRCUITRY IN MAMMALIAN LIMB DEVELOPMENT

Co-authors (left to right): Hongkai Ji, Steven Vokes, Andrew McMahon and Wing H. Wong The vertebrate limb has been one of the central models for understanding the problem…

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PERCEIVING SMELLS WITH SPARSE CONNECTIONS

Many regions of the brain are organized in such a way that they form an ordered representation of our sensory experiences. Similar physical stimuli –nearby points of light…

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