Olfaction is a critical sense for many animals, guiding their foraging behavior, mate choice and predator avoidance. Mice use ~1000 odorant receptor types in the main olfactory system…
(L to R) Vladimir Denic and Fei Wang Membrane protein targeting is a fundamental problem in cell biology. Pioneering work by George Palade in the 1960s established that…
The neuromuscular junction on the top is from a young adult mouse; that on the bottom from an 2-year old mouse, which is quite old for a mouse.…
Christopher Gregg and Catherine Dulac Parents influence the brain development and the behavior of their offspring in extraordinary and varied ways that impact the success of their offspring…
A three-way collaboration between the laboratories of Rich Losick in MCB and Roberto Kolter and Jon Clardy at Harvard Medical School has led to the discovery of a…
Cadherin-23 stretching simulations. A close-up view of the linker region between cadherin-23 repeats 1 and 2 is shown during a molecular dynamics simulation in which the protein is…
(L to R)Nadine Vastenhouw and Alexander Schier The genomes of most animals are inactive for hours or days after fertilization. Transcription is only initiated during the maternal-zygotic transition…
(L to R) Beth Weiner, Nancy Kleckner, Alison Grinthal, and Martin Karplus There is widespread current interest in the roles of mechanical forces for basic cellular process. Many…
(L to R)Alexander Schier and Jason Rihel Many psychiatric drugs were discovered decades ago through serendipity. For example, a tuberculosis drug called iproniazid also happened to make people…
(L to R) Linda Turner, Rongjing Zhang, and Howard C. Berg When grown on a rich medium on agar, many bacteria elongate, produce more flagella, and swim in…
