Elucidation and study of biosynthetic pathways and enzymes as well as the development of synthetic methods that are compatible with microbial chemistry.
Molecular mechanisms underlying viral genomic RNA – host interactions
Mechanisms of membrane-associated cell biological processes.
High resolution dynamic and spatial studies of prokaryotic cellular organization
Structural biology of signaling and transport through biological membranes
Molecular mechanisms of social behaviors, specifically self versus non-self recognition, in bacteria
Microbial eco-systems biology; Microbial physiology; Marine biogeochemistry
Mechanisms of antibiotics and antibiotic resistance
Chromosomes: motion, mechanics, DNA dynamics and spatial patterning
Development of chemical and molecular biology tools to allow new measurements and perturbations in biological systems; study mechanisms of gene regulation and dysregulation in cancer.
Chemical and synthetic biology, molecular evolution
Multicolor and time-resolved electron microscopy of cell signaling
Small molecule probes and therapeutics controlling gene expression, epigenetics, and cell states
Development and application of chemical proteomic methods to study the interactions of therapeutics, natural products, and metabolites within the cellular proteome
Single-molecule and super-resolution studies of cellular processes