Developing approaches to aid neuronal regeneration in the context of neurodegenerative diseases of the cortical output circuitry; modulating neuronal function in psychiatric diseases affecting cortical microcircuitry
Elucidation and study of biosynthetic pathways and enzymes as well as the development of synthetic methods that are compatible with microbial chemistry.
Real-time systems analysis of signal transduction and genetic networks at the single cell level
Synaptic plasticity: cellular mechanisms, development of functional networks and links to behaviour
Evolution of molecular and developmental mechanisms controlling cell fate decisions
High resolution dynamic and spatial studies of prokaryotic cellular organization
Molecular mechanisms of social behaviors, specifically self versus non-self recognition, in bacteria
Development of chemical and molecular biology tools to allow new measurements and perturbations in biological systems; study mechanisms of gene regulation and dysregulation in cancer.
Neuroscience Head Tutor Santiago Ramón y Cajal Professor of Arts and Sciences
Quantitative studies of biological self-organization, and the architecture and dynamics of subcellular structures.
Force-induced denaturation of DNA, sequence heterogeneity and the dynamics of motor proteins, population growth and mutation in disordered media
Theoretical and experimental studies of self-assembly, DNA/chromosome structure, homology recognition, Roles for Mechanical Force Probes Using Single Molecules
Small molecule probes and therapeutics controlling gene expression, epigenetics, and cell states
Development and application of chemical proteomic methods to study the interactions of therapeutics, natural products, and metabolites within the cellular proteome
Assembly and function of neural circuits in the visual system (currently not taking students)