Harvard University COVID-19 updates
Developing approaches to aid neuronal regeneration in the context of neurodegenerative diseases of the cortical output circuitry; modulating neuronal function in psychiatric diseases affecting cortical microcircuitry
Elucidation and study of biosynthetic pathways and enzymes as well as the development of synthetic methods that are compatible with microbial chemistry.
Sensory biology and cell physiology
The molecular and neural circuit basis of behavioral individuality.
Gene regulation, epigenetics and single-cell technologies
Ecology and evolution of microbial symbioses.
Cellular fat metabolism and inter-organelle communication
Real-time systems analysis of signal transduction and genetic networks at the single cell level
Combining optics, protein engineering, chemistry, electrophysiology, simulation, and theory, at the levels of individual molecules, single cells, and whole, genetically modified, organisms.
Molecular mechanisms underlying viral genomic RNA – host interactions
Mechanisms of membrane-associated cell biological processes.
Evolutionary dynamics, experimental evolution, population genetics
(On sabbatical 2023-24)
Molecular and neural architecture of social behavior circuits
Computational and quantitative biology
Mechanisms of parasitic behavior manipulation across molecules, cells and circuits.
Synaptic plasticity: cellular mechanisms, development of functional networks and links to behaviour
Evolution of molecular and developmental mechanisms controlling cell fate decisions
High resolution dynamic and spatial studies of prokaryotic cellular organization
Structural biology of signaling and transport through biological membranes
Microbial eco-systems biology; Microbial physiology; Marine biogeochemistry
(On sabbatical 2023-24)
Study of the mechanics of biomolecules, and more generally the role of physical and evolutionary forces in shaping biological systems
Experience-dependent brain development; critical periods
The genetic basis of adaptive morphology and behavior.
Evolutionary, ecological, and genetic basis of speciation
Development and Regeneration of the Mammalian Skin
C. elegans genetics of intercellular RNAi signaling
Mechanisms of antibiotics and antibiotic resistance
Chromosomes: motion, mechanics, DNA dynamics and spatial patterning
Evolution of floral developmental genetic pathways
Development of the nervous system, synaptic plasticity, behavior and evolution
Development of chemical and molecular biology tools to allow new measurements and perturbations in biological systems; study mechanisms of gene regulation and dysregulation in cancer.
Synaptic structure and competition
Chemical and synthetic biology, molecular evolution
Study evolution, hybridization, and speciation - mainly in butterflies
(Not accepting graduate students 2023-2024)
Virus biophysics; imaging techniques for studying self-assembly
Reproductive and regenerative biology
Neuronal cell biology, neural circuits and olfaction
Quantitative studies of biological self-organization, and the architecture and dynamics of subcellular structures
Force-induced denaturation of DNA, sequence heterogeneity and the dynamics of motor proteins, population growth and mutation in disordered media
Understanding and harnessing the complexity of plant chemistry and metabolism
Theoretical and experimental studies of self-assembly, DNA/chromosome structure, homology recognition, Roles for Mechanical Force Probes Using Single Molecules
Multicolor and time-resolved electron microscopy of cell signaling
System biology, decision making, neurobiology
Evolutionary forces in humans and pathogens
Circuits and Behavior
Small molecule probes and therapeutics controlling gene expression, epigenetics, and cell states
Development, Regeneration, Evolutionary Biology
Neurobiology of perception and decision making
Uncovering the intrinsic and extrinsic regulators of stem cell function, and revealing how changes in stem cell activity impact tissue regeneration throughout life
Non-coding RNA biology, imprinted gene expression regulation, neurobiology
Discovering principles governing regenerative success in tetrapods
Development and application of chemical proteomic methods to study the interactions of therapeutics, natural products, and metabolites within the cellular proteome
Molecular and circuit mechanisms underlying behavior and plasticity
Single-molecule and super-resolution studies of cellular processes
Neural mechanisms underlying motor sequence learning
(On sabbatical Fall 2023)
Microbial development and gene regulation
Chromosome segregation, yeast sex, and evolution
Computational methods to identify functional genomic sequences and structures. Quest for conserved RNA structures
Assembly and function of neural circuits in the visual system (currently not taking students)